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11187 PKP3

11187

PKP3

plakophilin 3

protein-coding

Homo sapiens

基因描述

Type Description
Definition plakophilin 3

研究结论

Date Results Publications
2019-11-02 11:22:00 14-3-3sigma (also known as stratifin, encoded by SFN) interacted preferentially with S285-phosphorylated PKP3 to promote its accumulation at tricellular contact sites, leading to stable desmosomes. 29678907
2019-09-28 10:26:00 PKP3 loss leads to an increase in invasion, tumor formation and metastasis and these phenotypes were dependent on the increase in LCN2 expression. 29803740
2019-05-25 10:25:00 The result of this study PKP3 as the oncogene candidate and a potential target for the treatment of ovarian cancer. 30527804
2019-05-18 11:19:00 Nasopharyngeal carcinoma (NPC) tissues display a significant high miR-149 and low PKP3 expressions indicating that both play an important role in NPC metastasis. Downregulation of miR-149 resulting in the increment of PKP3 expression. Also, N,N'-dinitrosopiperazine (DNP)-mediated PKP3 decrease was eliminated by miR-149 in NPC cells. This suggests that DNP may reduce PKP3 expression through upregulating miR-149. 30144176
2019-01-12 10:32:00 plakophilin 3 appears to be involved in tumor invasion in malignant mesothelioma 29722422

名称对应

Type IDs
Gene
UniProtKB-ID: PKP3_HUMAN
UniprotKB: Q9Y446
UniParc: UPI000213F88A, UPI0000034ACC
EMBL: FN421477, AF053719, DA439471, BC000081, AK223511, Z98265
Ensembl: ENSG00000184363
KO: hsa:11187
Nucleutide sequences
EMBL-CDS: BAD97231.1, CAZ65731.1, CAB44310.1, AAF23050.1, AAH00081.1
Ensembl_TRS: ENST00000331563
Protein sequencees
Ensembl_PRO: ENSP00000331678
RefSeq: NP_001289958.1, NP_009114.1
Others
UniRef100: UniRef100_Q9Y446
UniRef90: UniRef90_Q9Y446
UniRef50: UniRef50_Q9Y446
UniGene: Hs.534395
CCDS: CCDS7695.1

全选

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研究热度

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