| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase kinase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:17:00 | Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies. | 32860752 |
| 2020-10-24 14:09:00 | Hematopoietic progenitor kinase 1 down-regulates the oncogenic receptor tyrosine kinase AXL in pancreatic cancer. | 31959629 |
| 2018-06-16 10:26:00 | Interactions between HPK1 and its adaptor proteins related to immunity has been discussed (Review). | 28901492 |
| 2018-05-26 10:14:00 | HPK1 protein expression, which is expressed at significantly higher levels in NATs compared with paired IDC-NOS tissues, is significantly negatively associated with ER positivity and is positively associated with OS duration, suggesting that HPK1 may exhibit anticancer activities. | 28765906 |
| 2014-05-03 10:35:00 | CUL7/Fbxw8 ubiquitin ligase-mediated HPK1 degradation revealed a direct link and novel role of CUL7/Fbxw8 ubiquitin ligase in the MAPK pathway, which plays a critical role in cell proliferation and differentiation. | 24362026 |
| Type | IDs |
|---|---|
| Synonymous | HPK1 |
| Gene |
UniProtKB-ID:
M4K1_HUMAN
UniprotKB:
Q92918
UniParc:
UPI000020228B,
UPI00000747ED
EMBL:
AC008649,
AC005933,
U66464
Ensembl:
ENSG00000282928,
ENSG00000104814
KO:
hsa:11184
|
| Nucleutide sequences |
EMBL-CDS:
AAB97983.1
Ensembl_TRS:
ENST00000634494,
ENST00000634395,
ENST00000396857,
ENST00000591517
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000380066,
ENSP00000489158,
ENSP00000489001,
ENSP00000465039
RefSeq:
XP_011524706.1,
NP_001036065.1,
XP_016881720.1,
NP_009112.1,
XP_011524705.1
|
| Others |
UniRef100:
UniRef100_Q92918
UniRef90:
UniRef90_Q92918
UniRef50:
UniRef50_Q92918
UniGene:
Hs.95424
CCDS:
CCDS42564.1,
CCDS59385.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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