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111519 Igl

111519

Igl

immunoglobulin lambda chain complex

protein-coding

Mus musculus

基因描述

Type Description
Definition immunoglobulin lambda chain complex

研究结论

Date Results Publications
2014-03-29 11:13:00 2 state-4 regions distal to the VlambdaJlambda cassettes are highly conserved . These regions may represent shadow enhancers, which are suspected to serve as booster or redundancy elements for the regulation of many genes. 24353267
2014-01-18 11:56:00 Systematic deletion of known individual hypersensitive sites showed that HS1, which forms the major part of the transcription enhancer, Elambda3-1, is essential for Iglambda recombination and that it also helps to restrict Iglambda stage-specific recombination. 24383080
2010-01-21 00:00:00 A kappa recombination signal sequence and its flanks support six- to nine-fold higher levels of recombination than a lambda counterpart. 16054218
2010-01-21 00:00:00 Immunoglobulin lambda chain deficiency allows heavy (H) chain retention in the cytoplasm, but prevents H chain release from the cell, and as a result secondary lymphoid organs are B cell depleted while T cell levels remain normal. 12538695

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Type IDs
Synonymous Igl-x