| Type | Description |
|---|---|
| Definition | butyrophilin subfamily 3 member A1 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-26 13:09:00 | BTN3A1 governs antitumor responses by coordinating alphabeta and gammadelta T cells. | 32820120 |
| 2020-04-18 12:40:00 | We identified four Type 1 diabetes (T1D) risk loci reaching genome-wide significance in the Chinese Han population, including two novel loci: rs4320356 near BTN3A1, rs3802604 in GATA3, and two previously reported loci: rs1770 in MHC and rs705699 in SUOX. A higher genetic risk score were associated with an earlier age of T1D diagnosis and lower fasting C-peptide levels in individuals newly diagnosed with T1D. | 31152121 |
| 2020-04-18 11:46:00 | this study identified butyrophilin 2A1 (BTN2A1) as a key ligand that binds to the Vgamma9(+) TCR gamma chain | 31919129 |
| 2020-04-18 11:07:00 | Despite maintaining surface expression, BTN3A1 mutagenesis either abrogated or decreased stimulation by (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate demonstrating that the coiled-coil domains of BTN3A1 play critical roles for its function. | 31227581 |
| 2019-09-21 11:56:00 | Crystal structures of intracellular butyrophilin 3A proteins alone or in complex with the potent microbial phosphoantigen HMBPP or a synthetic analog revealed key features of phosphoantigens and butyrophilins required for gammadelta T cell activation. HMBPP binding to butyrophilin doubled the binding force between a gammadelta T cell and a target cell during "outside" signaling, as measured by single-cell force microsc... | 30902636 |
| Type | IDs |
|---|---|
| Synonymous | BT3.1, BTF5, BTN3.1, CD277 |
| Gene |
UniProtKB-ID:
BT3A1_HUMAN,
A8K547_HUMAN
UniprotKB:
O00481,
A8K547
UniParc:
UPI00001D4712,
UPI000192952F,
UPI000013C904,
UPI0001929530,
UPI00015DA71D
EMBL:
U90552,
AK299327,
CH471087,
AK295720,
Y07827,
AK223474,
AK291162,
AK290193,
BC121800,
BC118586,
AL021917
Ensembl:
ENSG00000026950
KO:
hsa:11119
|
| Nucleutide sequences |
EMBL-CDS:
CAA69164.1,
EAW55566.1,
AAI21801.1,
BAG58563.1,
AAI18587.1,
BAF82882.1,
EAW55567.1,
AAB53430.1,
BAD97194.1,
BAG61334.1,
BAF83851.1
Ensembl_TRS:
ENST00000414912,
ENST00000425234,
ENST00000289361,
ENST00000476549
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000406667,
ENSP00000289361,
ENSP00000420010,
ENSP00000396684
RefSeq:
XP_006715046.1,
XP_005248890.1,
NP_008979.3,
NP_001138480.1,
NP_001138481.1,
XP_005248891.1,
NP_919423.1
|
| Others |
UniRef100:
UniRef100_A8K547,
UniRef100_O00481
UniRef90:
UniRef90_O00481-2,
UniRef90_O00481
UniRef50:
UniRef50_O00481-3,
UniRef50_O00481
UniGene:
Hs.191510
CCDS:
CCDS47389.1,
CCDS4608.1,
CCDS4609.1,
CCDS47388.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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