| Type | Description |
|---|---|
| Definition | PR/SET domain 5 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-19 11:40:00 | Truncations may be the primary mutation type in PITX2. Glaucoma onset may be earlier in patients with mutations in PITX2 than in those without mutations in PITX2 and FOXC1. A block of the anterior chamber angle by the end of the iris might represent the main factor influencing the development of glaucoma in ARS patients with an asymmetric aniridia phenotype. | 29939776 |
| 2018-03-31 10:46:00 | Inhibiting PRDM5 expression by siRNA attenuated the IFN-gamma-triggered accumulation of active caspase-3 and cleaved in intestinal epithelial cells. Moreover, flow cytometry assay and CCK-8 analysis revealed that PRDM5 knockdown significantly alleviated the IFN-gamma-induced cellular apoptosis in HT29 cells. | 28476379 |
| 2017-08-12 10:25:00 | Both Prdm 4 and Prdm 5 are expressed in human corneal endothelium, primary hCECs and in HCECs-12 cells, characterised by expression of the Na(+)/K(+)-ATPase. | 28228349 |
| 2017-07-01 12:42:00 | The miR-182 promoter is rarely methylated in epithelial ovarian cancers (EOCs), and its methylation status is associated with lower miR-182 expression. Deletion of the PRDM5 locus may play a supportive role in miR-182 overexpression in EOC. miR-182 is an unfavorable prognostic factor in EOC. | 27295517 |
| 2017-03-11 12:18:00 | The current study revealed a novel mutation in the PRDM5 gene in a Brittle cornea syndrome (BCS) family and recurrent mutation in a sporadic BCS patient. | 27032025 |
| Type | IDs |
|---|---|
| Synonymous | BCS2, PFM2 |
| Gene |
UniProtKB-ID:
PRDM5_HUMAN
UniprotKB:
Q9NQX1
UniParc:
UPI0000DBDD85,
UPI0000DBDD84,
UPI00001A8315,
UPI000013D572
EMBL:
AF272897,
AC025741,
BC121037,
AC104795,
BC066942,
AK056352,
AC104068,
BC121038
Ensembl:
ENSG00000138738
KO:
hsa:11107
|
| Nucleutide sequences |
EMBL-CDS:
BAG51686.1,
AAI21039.1,
AAI21038.1,
AAF78077.1,
AAH66942.1
Ensembl_TRS:
ENST00000515109,
ENST00000428209,
ENST00000264808,
ENST00000394435
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000422309,
ENSP00000404832,
ENSP00000377955,
ENSP00000264808
RefSeq:
NP_001366035.1,
XP_011529871.1,
XP_011529867.1,
XP_016863158.1,
XP_016863160.1,
XP_024309647.1,
NP_061169.2,
XP_011529870.1,
XP_016863159.1,
NP_001287752.1,
XP_011529868.1,
XP_011529872.1,
XP_016863157.1,
XP_005262765.1,
XP_011529865.1,
NP_001366033.1,
XP_011529869.1,
NP_001287753.1,
XP_011529866.1
|
| Others |
UniRef100:
UniRef100_Q9NQX1
UniRef90:
UniRef90_Q9NQX1
UniRef50:
UniRef50_Q9NQX1
UniGene:
Hs.666782,
Hs.669312
CCDS:
CCDS75188.1,
CCDS3716.1,
CCDS75187.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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