| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase non-receptor type 21 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-13 11:14:00 | Study demonstrates that PTPN21 activates KIF1C by binding to the stalk region. This function does not require catalytic activity of the phosphatase, and its N-terminal FERM domain alone is sufficient to stimulate the transport of KIF1C cargoes in cells as well as increasing the landing rate of KIF1C on microtubules in vitro. The cargo adapter Hook3 binds KIF1C in the same region and activates KIF1C in a similar way. | 31217419 |
| 2015-04-18 11:20:00 | Presented data suggest that the transient formation of dynamic PTPD1/EGFR signalling complexes strengthens EGF signalling by promoting the spatial propagation of EGFR phosphorylated species | 25062045 |
| 2011-12-24 11:49:00 | The results that 2 non-synonymous markers in PTPN21 are associated with schizophrenia, further investigation of this locus is warranted. | 21752600 |
| 2011-01-15 11:16:00 | PTPD1 is a novel component of the endocytic machinery that impacts on EGF receptor stability and on growth and motility of bladder cancer cells | 20923765 |
| 2010-01-21 00:00:00 | PTPD1 is a component of a multivalent scaffold complex nucleated by FAK at specific intracellular sites | 18223254 |
| Type | IDs |
|---|---|
| Synonymous | PTPD1, PTPRL10 |
| Gene |
UniProtKB-ID:
PTN21_HUMAN
UniprotKB:
Q16825
UniParc:
UPI000013D15F
EMBL:
X79510,
AL162171
Ensembl:
ENSG00000070778
KO:
hsa:11099
|
| Nucleutide sequences |
EMBL-CDS:
CAA56042.1
Ensembl_TRS:
ENST00000556564,
ENST00000328736
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000452414,
ENSP00000330276
RefSeq:
XP_011534670.1,
XP_005267344.1,
XP_011534669.1,
XP_011534671.1,
NP_008970.2,
XP_016876428.1,
XP_006720074.1,
XP_016876427.1
|
| Others |
UniRef100:
UniRef100_Q16825
UniRef90:
UniRef90_Q16825
UniRef50:
UniRef50_Q16825
UniGene:
Hs.437040
CCDS:
CCDS9884.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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