| Type | Description |
|---|---|
| Definition | ADAM metallopeptidase with thrombospondin type 1 motif 8 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:04:00 | ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor. | 32033751 |
| 2020-08-01 15:10:00 | Study revealed upregulation of ADAMTS8 and downregulation of FRAS1 and SOSTDC1 in primary fibroblasts from linear morphoea (LM) lesions. SOSTDC1 knock-down recapitulated the reduced TGF -beta1 responsiveness and LM fibroblast migration, while overexpression of ADAMTS 8 induced myofibroblast markers. | 30367460 |
| 2019-08-17 10:17:00 | The expression level of ADAMTS8 mRNA increased 3.5 fold in Hip Degenerative Arthritis group when compared with Femoral neck fractures group. | 30655094 |
| 2017-12-09 12:50:00 | This study showed that ADAMTS1, 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer) | 28814085 |
| 2017-02-18 12:28:00 | ADAMTS8 hypermethylation is associated with decreased expression in gastric cancer. | 27493958 |
| Type | IDs |
|---|---|
| Synonymous | ADAM-TS8, METH2 |
| Gene |
UniProtKB-ID:
ATS8_HUMAN,
Q5FWF1_HUMAN
UniprotKB:
Q9UP79,
Q5FWF1
UniParc:
UPI000013CF5D,
UPI00004C96E5
EMBL:
BC089435,
AF060153,
AP002986,
AF175283
Ensembl:
ENSG00000134917
KO:
hsa:11095
|
| Nucleutide sequences |
EMBL-CDS:
AAF25806.1,
AAD48081.1,
AAH89435.1
Ensembl_TRS:
ENST00000257359
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000257359
RefSeq:
XP_016872634.1,
NP_008968.4
|
| Others |
UniRef100:
UniRef100_Q5FWF1,
UniRef100_Q9UP79
UniRef90:
UniRef90_Q9UP79,
UniRef90_A0A452TI86
UniRef50:
UniRef50_Q9UP79
UniGene:
Hs.271605
CCDS:
CCDS41732.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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