| Type | Description |
|---|---|
| Definition | aldo-keto reductase family 1 member C4 |
| Date | Results | Publications |
|---|---|---|
| 2017-04-22 10:05:00 | the present study suggests that AKR1C1, AKR1C2, AKR1C3, and AKR1C4 are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells. | 28259989 |
| 2014-08-30 10:13:00 | Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency. | 24189185 |
| 2013-01-26 11:42:00 | In women only, SNPs in AKR1C4 reduced the likelihood of having exhibited paranoid ideation by circa 60%. | 22356824 |
| 2011-11-12 11:30:00 | Low progesterone levels and a cystine to serine change at position 145 in AKR1C4 gene are associated with manic/hypomanic irritability in males | 21570127 |
| 2011-09-03 11:40:00 | role of AKR1C4 in the metabolism of testosterone and progesterone via the 5beta-reductase pathway. | 21521174 |
| Type | IDs |
|---|---|
| Synonymous | 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA |
| Gene |
UniProtKB-ID:
AK1C4_HUMAN
UniprotKB:
P17516
UniParc:
UPI000013D3B2
EMBL:
AB031085,
S68287,
D26125,
AL355303,
BC020744,
AB045829,
M33375,
AB032163
Ensembl:
ENSG00000198610
KO:
hsa:1109
|
| Nucleutide sequences |
EMBL-CDS:
AAD14010.1,
AAH20744.1,
BAA92885.1,
BAA92893.1,
BAA99542.1,
BAA05122.1,
AAA35658.1
Ensembl_TRS:
ENST00000263126,
ENST00000380448
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000263126,
ENSP00000369814
RefSeq:
NP_001809.4
|
| Others |
UniRef100:
UniRef100_P17516
UniRef90:
UniRef90_P17516
UniRef50:
UniRef50_P17516
UniGene:
Hs.567245
CCDS:
CCDS7064.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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