| Type | Description |
|---|---|
| Definition | protein phosphatase 2 protein activator |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 12:17:00 | results implicate a critical role of UBE3A-PTPA-PP2A signaling in the pathogenesis of UBE3A-related disorders and suggest that PP2A-based drugs could be potential therapeutic candidates for treatment of UBE3A-related disorders | 31160454 |
| 2018-01-06 12:29:00 | Evidence for PPP2R4 as a haploinsufficient tumor suppressor gene, defining a high-penetrance genetic mechanism for PP2A inhibition in human cancer. | 29046336 |
| 2016-06-28 11:47:00 | data indicate that PTPalpha and FAK, which are enriched in FAs, interact with IP3R1 at adjacent ER sites to spatially sequester IL-1-induced Ca(2+) signalling | 26611753 |
| 2010-01-21 00:00:00 | oxidative stress regulates the phosphorylation status of nonribosomal rpS3 by both activating and blocking the PP2A interaction with rpS3 | 19458393 |
| 2010-01-21 00:00:00 | findings show that ectopic expression of the phosphotyrosyl phosphatase activator PTPA induces cell death in mammalian cells via a mechanism involving caspase-3-dependent apoptosis | 17333320 |
| Type | IDs |
|---|---|
| Synonymous | 2610042B21Rik, C77440, N28142, PR53, Ppp2r4 |
| Gene |
UniProtKB-ID:
PTPA_MOUSE,
Q543N6_MOUSE
UniprotKB:
P58389,
Q543N6
UniParc:
UPI000000407D
EMBL:
BC006626,
AK150029,
BC052852,
AY035997,
AK049184,
AK046288
Ensembl:
ENSMUSG00000039515
KO:
mmu:110854
|
| Nucleutide sequences |
EMBL-CDS:
AAH52852.1,
AAH06626.1,
AAK62028.1,
BAE29253.1,
BAC33594.1,
BAC32672.1
Ensembl_TRS:
ENSMUST00000042055
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000046837
RefSeq:
NP_001349662.1,
NP_001349663.1,
NP_620087.3
|
| Others |
UniRef100:
UniRef100_P58389
UniRef90:
UniRef90_P58389
UniRef50:
UniRef50_Q15257
UniGene:
Mm.275393
CCDS:
CCDS15883.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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