Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.

Mol Cell Proteomics     Domenico Fasci , Hugo van Ingen , Richard A Scheltema , Albert J R Heck

Architecture of the human interactome defines protein communities and disease networks.

Nature     Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.

EBioMedicine     Florent Letronne , Geoffroy Laumet , Anne-Marie Ayral , Julien Chapuis , Florie Demiautte , Mathias Laga , Michel E Vandenberghe , Nicolas Malmanche , Florence Leroux , Fanny Eysert , Yoann Sottejeau , Linda Chami , Amandine Flaig , Charlotte Bauer , Pierre Dourlen , Marie Lesaffre , Charlotte Delay , Ludovic Huot , Julie Dumont , Elisabeth Werkmeister , Franck Lafont , Tiago Mendes , Franck Hansmannel , Bart Dermaut , Benoit Deprez , Anne-Sophie Hérard , Marc Dhenain , Nicolas Souedet , Florence Pasquier , David Tulasne , Claudine Berr , Jean-Jacques Hauw , Yves Lemoine , Philippe Amouyel , David Mann , Rebecca Déprez , Frédéric Checler , David Hot , Thierry Delzescaux , Kris Gevaert , Jean-Charles Lambert

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Nature     Luke Jostins , Stephan Ripke , Rinse K Weersma , Richard H Duerr , Dermot P McGovern , Ken Y Hui , James C Lee , L Philip Schumm , Yashoda Sharma , Carl A Anderson , Jonah Essers , Mitja Mitrovic , Kaida Ning , Isabelle Cleynen , Emilie Theatre , Sarah L Spain , Soumya Raychaudhuri , Philippe Goyette , Zhi Wei , Clara Abraham , Jean-Paul Achkar , Tariq Ahmad , Leila Amininejad , Ashwin N Ananthakrishnan , Vibeke Andersen , Jane M Andrews , Leonard Baidoo , Tobias Balschun , Peter A Bampton , Alain Bitton , Gabrielle Boucher , Stephan Brand , Carsten Büning , Ariella Cohain , Sven Cichon , Mauro D'Amato , Dirk De Jong , Kathy L Devaney , Marla Dubinsky , Cathryn Edwards , David Ellinghaus , Lynnette R Ferguson , Denis Franchimont , Karin Fransen , Richard Gearry , Michel Georges , Christian Gieger , Jürgen Glas , Talin Haritunians , Ailsa Hart , Chris Hawkey , Matija Hedl , Xinli Hu , Tom H Karlsen , Limas Kupcinskas , Subra Kugathasan , Anna Latiano , Debby Laukens , Ian C Lawrance , Charlie W Lees , Edouard Louis , Gillian Mahy , John Mansfield , Angharad R Morgan , Craig Mowat , William Newman , Orazio Palmieri , Cyriel Y Ponsioen , Uros Potocnik , Natalie J Prescott , Miguel Regueiro , Jerome I Rotter , Richard K Russell , Jeremy D Sanderson , Miquel Sans , Jack Satsangi , Stefan Schreiber , Lisa A Simms , Jurgita Sventoraityte , Stephan R Targan , Kent D Taylor , Mark Tremelling , Hein W Verspaget , Martine De Vos , Cisca Wijmenga , David C Wilson , Juliane Winkelmann , Ramnik J Xavier , Sebastian Zeissig , Bin Zhang , Clarence K Zhang , Hongyu Zhao , International IBD Genetics Consortium (IIBDGC) , Mark S Silverberg , Vito Annese , Hakon Hakonarson , Steven R Brant , Graham Radford-Smith , Christopher G Mathew , John D Rioux , Eric E Schadt , Mark J Daly , Andre Franke , Miles Parkes , Severine Vermeire , Jeffrey C Barrett , Judy H Cho

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.

Brief. Bioinformatics     Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas

PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

PLoS ONE     Cheng Hu , Rong Zhang , Congrong Wang , Jie Wang , Xiaojing Ma , Jingyi Lu , Wen Qin , Xuhong Hou , Chen Wang , Yuqian Bao , Kunsan Xiang , Weiping Jia

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

Diabetes     Hana Lango , UK Type 2 Diabetes Genetics Consortium , Colin N A Palmer , Andrew D Morris , Eleftheria Zeggini , Andrew T Hattersley , Mark I McCarthy , Timothy M Frayling , Michael N Weedon

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Nat Genet     Eleftheria Zeggini , Laura J Scott , Richa Saxena , Benjamin F Voight , Jonathan L Marchini , Tianle Hu , Paul I W de Bakker , Gonçalo R Abecasis , Peter Almgren , Gitte Andersen , Kristin Ardlie , Kristina Bengtsson Boström , Richard N Bergman , Lori L Bonnycastle , Knut Borch-Johnsen , Noël P Burtt , Hong Chen , Peter S Chines , Mark J Daly , Parimal Deodhar , Chia-Jen Ding , Alex S F Doney , William L Duren , Katherine S Elliott , Michael R Erdos , Timothy M Frayling , Rachel M Freathy , Lauren Gianniny , Harald Grallert , Niels Grarup , Christopher J Groves , Candace Guiducci , Torben Hansen , Christian Herder , Graham A Hitman , Thomas E Hughes , Bo Isomaa , Anne U Jackson , Torben Jørgensen , Augustine Kong , Kari Kubalanza , Finny G Kuruvilla , Johanna Kuusisto , Claudia Langenberg , Hana Lango , Torsten Lauritzen , Yun Li , Cecilia M Lindgren , Valeriya Lyssenko , Amanda F Marvelle , Christa Meisinger , Kristian Midthjell , Karen L Mohlke , Mario A Morken , Andrew D Morris , Narisu Narisu , Peter Nilsson , Katharine R Owen , Colin N A Palmer , Felicity Payne , John R B Perry , Elin Pettersen , Carl Platou , Inga Prokopenko , Lu Qi , Li Qin , Nigel W Rayner , Matthew Rees , Jeffrey J Roix , Anelli Sandbaek , Beverley Shields , Marketa Sjögren , Valgerdur Steinthorsdottir , Heather M Stringham , Amy J Swift , Gudmar Thorleifsson , Unnur Thorsteinsdottir , Nicholas J Timpson , Tiinamaija Tuomi , Jaakko Tuomilehto , Mark Walker , Richard M Watanabe , Michael N Weedon , Cristen J Willer , Wellcome Trust Case Control Consortium , Thomas Illig , Kristian Hveem , Frank B Hu , Markku Laakso , Kari Stefansson , Oluf Pedersen , Nicholas J Wareham , Inês Barroso , Andrew T Hattersley , Francis S Collins , Leif Groop , Mark I McCarthy , Michael Boehnke , David Altshuler

The DNA sequence and biological annotation of human chromosome 1.

Nature     S G Gregory , K F Barlow , K E McLay , R Kaul , D Swarbreck , A Dunham , C E Scott , K L Howe , K Woodfine , C C A Spencer , M C Jones , C Gillson , S Searle , Y Zhou , F Kokocinski , L McDonald , R Evans , K Phillips , A Atkinson , R Cooper , C Jones , R E Hall , T D Andrews , C Lloyd , R Ainscough , J P Almeida , K D Ambrose , F Anderson , R W Andrew , R I S Ashwell , K Aubin , A K Babbage , C L Bagguley , J Bailey , H Beasley , G Bethel , C P Bird , S Bray-Allen , J Y Brown , A J Brown , D Buckley , J Burton , J Bye , C Carder , J C Chapman , S Y Clark , G Clarke , C Clee , V Cobley , R E Collier , N Corby , G J Coville , J Davies , R Deadman , M Dunn , M Earthrowl , A G Ellington , H Errington , A Frankish , J Frankland , L French , P Garner , J Garnett , L Gay , M R J Ghori , R Gibson , L M Gilby , W Gillett , R J Glithero , D V Grafham , C Griffiths , S Griffiths-Jones , R Grocock , S Hammond , E S I Harrison , E Hart , E Haugen , P D Heath , S Holmes , K Holt , P J Howden , A R Hunt , S E Hunt , G Hunter , J Isherwood , R James , C Johnson , D Johnson , A Joy , M Kay , J K Kershaw , M Kibukawa , A M Kimberley , A King , A J Knights , H Lad , G Laird , S Lawlor , D A Leongamornlert , D M Lloyd , J Loveland , J Lovell , M J Lush , R Lyne , S Martin , M Mashreghi-Mohammadi , L Matthews , N S W Matthews , S McLaren , S Milne , S Mistry , M J F Moore , T Nickerson , C N O'Dell , K Oliver , A Palmeiri , S A Palmer , A Parker , D Patel , A V Pearce , A I Peck , S Pelan , K Phelps , B J Phillimore , R Plumb , J Rajan , C Raymond , G Rouse , C Saenphimmachak , H K Sehra , E Sheridan , R Shownkeen , S Sims , C D Skuce , M Smith , C Steward , S Subramanian , N Sycamore , A Tracey , A Tromans , Z Van Helmond , M Wall , J M Wallis , S White , S L Whitehead , J E Wilkinson , D L Willey , H Williams , L Wilming , P W Wray , Z Wu , A Coulson , M Vaudin , J E Sulston , R Durbin , T Hubbard , R Wooster , I Dunham , N P Carter , G McVean , M T Ross , J Harrow , M V Olson , S Beck , J Rogers , D R Bentley , R Banerjee , S P Bryant , D C Burford , W D H Burrill , S M Clegg , P Dhami , O Dovey , L M Faulkner , S M Gribble , C F Langford , R D Pandian , K M Porter , E Prigmore

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

Genome Res.     Hilary F Clark , Austin L Gurney , Evangeline Abaya , Kevin Baker , Daryl Baldwin , Jennifer Brush , Jian Chen , Bernard Chow , Clarissa Chui , Craig Crowley , Bridget Currell , Bethanne Deuel , Patrick Dowd , Dan Eaton , Jessica Foster , Christopher Grimaldi , Qimin Gu , Philip E Hass , Sherry Heldens , Arthur Huang , Hok Seon Kim , Laura Klimowski , Yisheng Jin , Stephanie Johnson , James Lee , Lhney Lewis , Dongzhou Liao , Melanie Mark , Edward Robbie , Celina Sanchez , Jill Schoenfeld , Somasekar Seshagiri , Laura Simmons , Jennifer Singh , Victoria Smith , Jeremy Stinson , Alicia Vagts , Richard Vandlen , Colin Watanabe , David Wieand , Kathryn Woods , Ming-Hong Xie , Daniel Yansura , Sothy Yi , Guoying Yu , Jean Yuan , Min Zhang , Zemin Zhang , Audrey Goddard , William I Wood , Paul Godowski , Alane Gray