| Type | Description |
|---|---|
| Definition | cholinergic receptor, nicotinic, alpha polypeptide 5 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:55:00 | Chrna5 is Essential for a Rapid and Protected Response to Optogenetic Release of Endogenous Acetylcholine in Prefrontal Cortex. | 32817066 |
| 2020-05-02 10:41:00 | The majority of nicotinic receptors at the cell surface of superior cervical ganglia neurons consist of alpha3beta4alpha5 subunits. | 30891952 |
| 2019-10-26 10:21:00 | Deletion of the alpha5 subunit in mice markedly reduces the cellular response to nicotine and acetylcholine in the interpeduncular nucleus. Stimulation of alpha5-expressing IP neurons using optogenetics is aversive, but this effect requires priming by recent prior stimulation or exposure to nicotine. The smoking-associated variant of the alpha5 gene may increase the drive to smoke via loss of IP-mediated nicotine avers... | 29954848 |
| 2019-02-16 11:34:00 | Observations in hemiparkinsonian mice suggest that the lack of alpha5* nicotinic receptors results in attenuated dopaminergic neurodegeneration and motor dysfunction in a 6-OHDA neurotoxin model of Parkinson's disease; suggests potential for alpha5 subunit-containing nicotinic receptors as a novel target in the treatment of Parkinson's disease. | 29940207 |
| 2018-12-22 12:23:00 | Data suggest that the Chrna5 D398N variant influences the effect of developmental nicotine exposure on nicotine intake of exposed offspring. This gene-environment interaction on striatal DA release may provide motivation for increased nicotine seeking in N Nic offspring and reduced consumption in D Nic offspring. | 29573323 |
| Type | IDs |
|---|---|
| Synonymous | Acra-5, Acra5 |
| Gene |
UniProtKB-ID:
ACHA5_MOUSE,
Q8BIE9_MOUSE
UniprotKB:
Q2MKA5,
Q8BIE9
UniParc:
UPI000067C798,
UPI00000EB81A,
UPI000035938E
EMBL:
AY574264,
BC106853,
DQ318788,
AK080900
Ensembl:
ENSMUSG00000035594
KO:
mmu:110835
|
| Nucleutide sequences |
EMBL-CDS:
AAS90360.1,
AAI06854.1,
ABC49856.1,
BAC38070.1
Ensembl_TRS:
ENSMUST00000093844,
ENSMUST00000213960
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000091365,
ENSMUSP00000150942
RefSeq:
NP_001360830.1,
NP_001360831.1,
NP_789814.2,
XP_030099877.1
|
| Others |
UniRef100:
UniRef100_Q2MKA5,
UniRef100_Q8BIE9
UniRef90:
UniRef90_A0A1L1SR97,
UniRef90_P20420
UniRef50:
UniRef50_A0A2K6KMN9,
UniRef50_P30532
UniGene:
Mm.103778
CCDS:
CCDS52800.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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