| Type | Description |
|---|---|
| Definition | Rap guanine nucleotide exchange factor 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 12:21:00 | The authors conclude that Epac2/cAMP controls fusion pore expansion and thus the balance of hormone and transmitter release during insulin granule exocytosis. | 31099751 |
| 2019-03-30 10:24:00 | Through isoform-specific gene knockdown, the authors found that EPAC2, but not EPAC1, plays a dominant role in controlling RSV replication and virus-induced host responses. | 30185593 |
| 2018-11-03 12:00:00 | (cAMP), a secondary messenger responsible for various physiological processes regulates cell metabolism by activating Protein kinase A and by targeting exchange protein directly activated by cAMP (EPAC). EPAC is present in two isoforms EPAC1 and EPAC2, which exhibit different tissue distribution and is involved in GDP/GTP exchange along with activating Rap1- and Rap2-mediated signaling pathways. | 29417338 |
| 2018-03-10 10:49:00 | Study identifies Epac2-Rap1 signaling as a novel feedback mechanism in the heart, which controls mitochondrial reactive oxygen species production. | 27649969 |
| 2017-11-11 11:55:00 | rs17746510, one of the three single-nucleotide polymorphisms (SNPs) in RAPGEF4 associated with cognitive decline in Chinese Alzheimer's disease (AD) patients, was significantly correlated with apathy and mood disturbance | 27598965 |
| Type | IDs |
|---|---|
| Synonymous | CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496 |
| Gene |
UniProtKB-ID:
RPGF4_HUMAN,
B7Z278_HUMAN
UniprotKB:
Q8WZA2,
B7Z278
UniParc:
UPI00001AAC4B,
UPI0001914B4C,
UPI0001914B34,
UPI0000E07BAC,
UPI000006D4C7,
UPI00001AAC4C
EMBL:
AC009484,
U78516,
AC104086,
AK316072,
BC040183,
AK296340,
AK304278,
AK294914,
BC024004,
AK294445,
AC018712,
AB027471,
AK294433,
AC019046,
AK313084
Ensembl:
ENSG00000091428
KO:
hsa:11069
|
| Nucleutide sequences |
EMBL-CDS:
AAH40183.1,
BAB72179.1,
BAH12322.1,
BAH14443.1,
AAD03422.1,
BAH11769.1,
BAG35910.1,
BAH14148.1,
AAH24004.1,
BAH11923.1,
BAH11764.1
Ensembl_TRS:
ENST00000540783,
ENST00000538974,
ENST00000397087,
ENST00000397081,
ENST00000535187
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000380276,
ENSP00000440135,
ENSP00000440250,
ENSP00000380271,
ENSP00000438011
RefSeq:
NP_001362795.1,
NP_001362793.1,
NP_001362797.1,
NP_001362804.1,
NP_001362799.1,
NP_001269828.1,
XP_006712268.1,
NP_001362802.1,
XP_011508807.1,
NP_001269829.1,
NP_001362798.1,
XP_016858685.1,
NP_001362805.1,
NP_001362794.1,
NP_001362796.1,
NP_001269830.1,
NP_008954.2,
NP_001362803.1,
XP_016858686.1,
NP_001362800.1,
NP_001093867.1,
NP_001362801.1
|
| Others |
UniRef100:
UniRef100_Q8WZA2
UniRef90:
UniRef90_Q8WZA2
UniRef50:
UniRef50_Q8WZA2
UniGene:
Hs.470646
CCDS:
CCDS42776.1,
CCDS63061.1,
CCDS63060.1,
CCDS42775.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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