| Type | Description |
|---|---|
| Definition | ataxin 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-06 10:11:00 | ATXN3 positively regulates type I IFN antiviral response by deubiquitinating and stabilizing HDAC3 | 29802126 |
| 2019-03-09 11:40:00 | Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways | 30231063 |
| 2017-05-27 12:23:00 | findings identify a novel molecular link between ATX-3 and p53-mediated cell death and provide an explanation for the direct involvement of p53 in SCA3 disease pathogenesis | 27851749 |
| 2016-06-28 11:17:00 | We show that chronic VPA treatment did not modify the ATXN3 inclusion load and astrogliosis in affected brain regions However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects | 26505994 |
| 2016-05-07 11:57:00 | work suggests that in Machado-Joseph disease, mutant ataxin-3 drives an abnormal reduction of ataxin-2 levels, which overactivates poly(A)-binding protein, increases translation of mutant ataxin-3 and other proteins and aggravates Machado-Joseph disease. | 26490332 |
| Type | IDs |
|---|---|
| Synonymous | 2210008M02Rik, AI463012, AI647473, ATX3, MJD1, Mjd, Sca3, ataxin-3 |
| Gene |
UniProtKB-ID:
ATX3_MOUSE,
Q5M8S1_MOUSE,
Q810M8_MOUSE,
E9Q717_MOUSE,
Q546X9_MOUSE
UniprotKB:
Q9CVD2,
Q5M8S1,
Q810M8,
E9Q717,
Q546X9
UniParc:
UPI000012F16F,
UPI000017D9D5,
UPI00001E765B,
UPI00004A0461
EMBL:
AF537188,
AC121965,
AK030842,
BC049743,
AK008675,
BC087880
Ensembl:
ENSMUSG00000021189
KO:
mmu:110616
|
| Nucleutide sequences |
EMBL-CDS:
BAB25825.3,
BAC27155.1,
AAH87880.1,
AAH49743.1,
AAQ10750.1
Ensembl_TRS:
ENSMUST00000021606,
ENSMUST00000160251,
ENSMUST00000161011
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000021606,
ENSMUSP00000125082,
ENSMUSP00000125378
RefSeq:
NP_083981.2,
XP_036013055.1,
XP_030102386.1,
XP_030102382.1,
XP_036013057.1,
XP_030102383.1,
XP_036013056.1,
NP_001161386.1
|
| Others |
UniRef100:
UniRef100_Q9CVD2,
UniRef100_Q5M8S1,
UniRef100_Q810M8
UniRef90:
UniRef90_Q810M8,
UniRef90_Q5M8S1,
UniRef90_Q9CVD2
UniRef50:
UniRef50_P54252-1,
UniRef50_K7G901,
UniRef50_Q9CVD2
UniGene:
Mm.271914
CCDS:
CCDS26115.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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