| Type | Description |
|---|---|
| Definition | Pim-2 proto-oncogene, serine/threonine kinase |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:44:00 | PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-kappaB signaling pathway. | 32641749 |
| 2020-11-21 13:19:00 | TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells. | 31501481 |
| 2020-10-24 14:03:00 | Inhibition of PIM2 in liver cancer decreases tumor cell proliferation in vitro and in vivo primarily through the modulation of cell cycle progression. | 31894300 |
| 2020-06-06 13:25:00 | HSF1 protein stability is regulated by PIM2-mediated phosphorylation of HSF1 at Thr120. PIM2, pThr120-HSF1, and PD-L1 expression positively correlated with each other in breast cancer tissues. | 31409638 |
| 2020-02-01 11:38:00 | Phosphorylation of AMPKalpha1 by PIM2 led to decreasing AMPKalpha1 kinase activity, which in turn promoted aerobic glycolysis and tumor growth. In addition, PIM2 expression positively correlated with AMPKalpha1 Thr467 phosphorylation in Endometrial cancer tissues. Insights into the role of PIM2 and AMPKalpha1 in Endometrial cancer suggest that combination targeting of these proteins may represent a new strategy for tre... | 31358902 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
PIM2_HUMAN,
A0A024QYW7_HUMAN
UniprotKB:
Q9P1W9,
A0A024QYW7
UniParc:
UPI0000049044
EMBL:
AK290931,
CH471224,
U77735,
AF207550,
AB042425,
BC018111
Ensembl:
ENSG00000102096
KO:
hsa:11040
|
| Nucleutide sequences |
EMBL-CDS:
AAC78506.1,
BAF83620.1,
AAH18111.1,
BAA95613.1,
EAW50730.1,
EAW50729.1
Gene_ORFName:
hCG_19826
Ensembl_TRS:
ENST00000376509
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000365692
RefSeq:
NP_006866.2
|
| Others |
UniRef100:
UniRef100_Q9P1W9
UniRef90:
UniRef90_Q9P1W9
UniRef50:
UniRef50_Q9P1W9
UniGene:
Hs.727148
CCDS:
CCDS14312.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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