| Type | Description |
|---|---|
| Definition | TRIO and F-actin binding protein |
| Date | Results | Publications |
|---|---|---|
| 2020-08-29 12:46:00 | TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing. | 31217345 |
| 2017-08-19 12:31:00 | missense mutations in the Pejvakin (PJVK or DFNB59) gene were first identified in patients with audiological hallmarks of auditory neuropathy spectrum disorder, whereas all other PJVK alleles cause hearing loss of cochlear origin. These findings suggest that complex pathogenetic mechanisms underlie human deafness DFNB59. | 28209736 |
| 2014-01-04 12:28:00 | R1 motif is the major actin-binding domain of TRIOBP-4, and the binding of R2 motif with actin filaments is nonspecific. | 23789641 |
| 2011-07-16 11:30:00 | Tara activates Rac1 through the Trio RhoGEF, which binds to E-cadherin and subsequently increases the phosphorylation of p38 and Tbx3, a transcriptional E-cadherin repressor. | 21482718 |
| 2010-06-28 11:58:00 | mutant Triobp mice are profoundly deaf; stereocilia of Triobp mice develop normally but fail to form rootlets and are easier to deflect and damage. | 20510926 |
| Type | IDs |
|---|---|
| Synonymous | AI428493, EST478828, Tara, mKIAA1662 |
| Gene |
UniProtKB-ID:
TARA_MOUSE,
A0A2U3TZ82_MOUSE
UniprotKB:
Q99KW3,
A0A2U3TZ82
UniParc:
UPI000067B3FC,
UPI00000E9AD3,
UPI00006C21C1,
UPI00006A77A3,
UPI000067B3FB,
UPI0000682C27
EMBL:
BC003984,
AL589670,
AK170390,
AK129417,
AK053194,
DQ228002,
BC042760,
DQ278602,
DQ228000,
DQ228001,
BC053329
Ensembl:
ENSMUSG00000033088
KO:
mmu:110253
|
| Nucleutide sequences |
EMBL-CDS:
ABB59558.2,
AAH53329.1,
ABB59556.1,
BAC98227.2,
AAH03984.1,
BAE41764.1,
ABB59557.2,
AAH42760.1,
ABB77203.1,
BAC35308.1
Ensembl_TRS:
ENSMUST00000140228,
ENSMUST00000109690,
ENSMUST00000109689,
ENSMUST00000109687
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000155397,
ENSMUSP00000105312,
ENSMUSP00000105311,
ENSMUSP00000105309
RefSeq:
XP_006520347.1,
XP_006520354.1,
XP_036014965.1,
NP_613045.3,
XP_006520348.1,
NP_001034245.1,
XP_036014964.1,
XP_006520350.1,
NP_001034244.1,
NP_001019887.1,
XP_006520352.1,
XP_036014963.1,
XP_006520349.1,
XP_017171854.1
|
| Others |
UniRef100:
UniRef100_A0A2U3TZ82,
UniRef100_Q99KW3
UniRef90:
UniRef90_Q99KW3,
UniRef90_A0A0G2K6B2
UniRef50:
UniRef50_Q9H2D6-7,
UniRef50_Q99KW3
UniGene:
Mm.123714
CCDS:
CCDS37136.1,
CCDS37137.1,
CCDS88802.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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