| Type | Description |
|---|---|
| Definition | serine peptidase inhibitor, Kazal type 5 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:22:00 | LEKTI domains D6, D7 and D8+9 serve as substrates for transglutaminase 1: implications for targeted therapy of Netherton syndrome. | 30801672 |
| 2021-01-23 12:56:00 | Exonic mutations associated with atopic dermatitis disrupt lympho-epithelial Kazal-type related inhibitor action and enhance its degradation. | 31407378 |
| 2020-08-22 15:28:00 | Genetic polymorphisms in serine protease inhibitor Kazal-type 5 and risk of atopic dermatitis: A meta-analysis. | 32664181 |
| 2020-07-04 10:17:00 | Our study shows that SPINK5 can inhibit the proliferation, migration, and invasion of esophageal cancer cells by inhibiting Wnt/beta-catenin signaling pathway, and thus plays an important role in the development of esophageal cancer, and may serve as a treatment target of esophageal cancer. | 30868765 |
| 2020-04-04 12:11:00 | TNF-alpha and IL-17A significantly induced the expression of LEKTI in NHEKs. The immunohistochemical and tape-stripping analysis revealed that psoriatic skin lesions had higher LEKTI expression compared to normal skin and atopic dermatitis (AD) lesions. TNF-alpha and IL-17A induce the expression of serine protease inhibitor LEKTI, and it might occur to suppress the increase in the serine protease activities under infla... | 31501002 |
| Type | IDs |
|---|---|
| Synonymous | LEKTI, LETKI, NETS, NS, VAKTI |
| Gene |
UniProtKB-ID:
ISK5_HUMAN
UniprotKB:
Q9NQ38
UniParc:
UPI000020CF22,
UPI000020CF25,
UPI0000414666
EMBL:
AJ391247,
AJ391236,
AF295784,
AJ228139,
AJ391241,
AJ276578,
AJ391242,
AJ391234,
AJ391243,
AJ270944,
AJ391249,
AJ391231,
AJ391230,
AJ276579,
AJ391246,
AJ391237,
AJ276580,
AJ391244,
AJ391233,
AJ276577,
AJ391238,
AJ391253,
AC116334,
AJ391232,
AC008722,
DQ149927,
AJ391240,
AJ391248,
AJ391251,
AJ391252,
DQ149929,
AJ391245,
AJ391235,
DQ149928,
AJ391239,
AJ391250,
AF295783,
AJ391254
Ensembl:
ENSG00000133710
KO:
hsa:11005
|
| Nucleutide sequences |
EMBL-CDS:
CAB96877.1,
ABA06535.1,
AAK97140.1,
ABA06536.1,
ABA06534.1,
CAB40839.1,
AAK97139.1
Ensembl_TRS:
ENST00000359874,
ENST00000256084,
ENST00000398454
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000256084,
ENSP00000381472,
ENSP00000352936
RefSeq:
NP_006837.2,
NP_001121171.1,
NP_001121170.1,
XP_011535853.1
|
| Others |
UniRef100:
UniRef100_Q9NQ38
UniRef90:
UniRef90_Q9NQ38
UniRef50:
UniRef50_Q9NQ38
UniGene:
Hs.331555
CCDS:
CCDS47301.1,
CCDS43382.1,
CCDS47300.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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