| Type | Description |
|---|---|
| Definition | argininosuccinate lyase |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 11:28:00 | Mechanistically, KLF7 transcriptionally activated argininosuccinate lyase (ASL), which was observed highly expressed in glioma tissues. KLF7 accelerates the xenografted tumor growth of glioma cells. KLF7 potentiates polyamine biosynthesis and glioma cell growth via transcriptionally activates ASL. | 31018905 |
| 2019-06-22 10:52:00 | We designed a codon-optimized human ASL gene packaged within adeno-associated virus serotype 8 (AAV8) as a vector for targeted delivery to the liver. To evaluate the therapeutic efficacy of this approach, we utilized a murine hypomorphic model of ASA. Neonatal administration of AAV8 via the temporal facial vein extended survival in ASA hypomorphic mice, although not to wild-type levels. | 30253962 |
| 2014-10-04 12:07:00 | Enterocyte-derived ASL has a protective role in necrotizing enterocolitis. | 24904080 |
| Type | IDs |
|---|---|
| Synonymous | 2510006M18Rik, ASAL |
| Gene |
UniProtKB-ID:
ARLY_MOUSE
UniprotKB:
Q91YI0
UniParc:
UPI0000004109
EMBL:
AK168739,
BC016670,
AK076453,
AK148764,
AK140160
Ensembl:
ENSMUSG00000025533
KO:
mmu:109900
|
| Nucleutide sequences |
EMBL-CDS:
BAE28659.1,
BAE40580.1,
AAH16670.1,
BAE24262.1,
BAC36348.1
Ensembl_TRS:
ENSMUST00000159619,
ENSMUST00000161094,
ENSMUST00000160129
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000124274,
ENSMUSP00000123799,
ENSMUSP00000124579
RefSeq:
XP_036020620.1,
NP_598529.1,
XP_006504404.1
|
| Others |
UniRef100:
UniRef100_Q91YI0
UniRef90:
UniRef90_P20673
UniRef50:
UniRef50_P04424
UniGene:
Mm.23869
CCDS:
CCDS51655.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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