| Type | Description |
|---|---|
| Definition | Braf transforming gene |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:25:00 | Activated Hgf-Met Signaling Cooperates with Oncogenic BRAF to Drive Primary Cutaneous Melanomas and Angiotropic Lung Metastases in Mice. | 31972251 |
| 2020-11-21 13:15:00 | Differences in tumor initiation and progression of melanoma in the Braf(CA) ;Tyr-CreERT2;Pten(f/f) model between male and female mice. | 31449725 |
| 2020-05-16 11:40:00 | Here, we show that endothelial cell-restricted ablation of BRAF, a kinase frequently activated in cancer, prevents vascular leaking as well metastatic spread. BRAF regulates endothelial permeability by promoting the cytoskeletal rearrangements necessary for the remodeling of VE-Cadherin-containing endothelial cell-cell junctions and the formation of intercellular gaps | 30828992 |
| 2020-03-14 10:25:00 | In this study, we demonstrate that CD34(+) and CD34(-) subpopulations carrying the BRAF(V600E) mutation confer differential sensitivity to targeted BRAF inhibition. Through elevated KDM5B expression, melanoma cells shift toward a more drug-tolerant, CD34(-) state upon exposure to BRAF inhibitor or combined BRAF inhibitor and MEK inhibitor treatment | 30523048 |
| 2020-03-07 10:22:00 | Pten loss is required to overcome inhibitory pathways induced by BRAF V600E expression. | 31527903 |
| Type | IDs |
|---|---|
| Synonymous | 9930012E13Rik, AA120551, AA387315, AA473386, B-raf, Braf-2, Braf2, C230098H17, C87398, D6Ertd631e |
| Gene |
UniProtKB-ID:
BRAF_MOUSE
UniprotKB:
P28028
UniParc:
UPI0000D62782,
UPI0000EADF13
EMBL:
AC122345,
M64429,
AK140431,
AC163109
Ensembl:
ENSMUSG00000002413
KO:
mmu:109880
|
| Nucleutide sequences |
EMBL-CDS:
BAE24384.1,
AAA37320.1
Ensembl_TRS:
ENSMUST00000002487
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000002487
RefSeq:
XP_036021641.1,
XP_006505421.1,
XP_011239437.1,
XP_011239438.2,
XP_036021642.1,
XP_036021643.1,
XP_036021640.1,
XP_030110954.1,
XP_011239436.1,
XP_006505416.1,
XP_030110955.1,
XP_036021639.1,
XP_011239439.2,
XP_006505418.1,
NP_647455.3,
XP_011239440.1,
XP_011239441.1
|
| Others |
UniRef100:
UniRef100_P28028
UniRef90:
UniRef90_P28028
UniRef50:
UniRef50_P28028
UniGene:
Mm.245513,
Mm.489691
CCDS:
CCDS39463.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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