| Type | Description |
|---|---|
| Definition | cleavage and polyadenylation factor I subunit 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-12 10:11:00 | We have reconstituted CF II as a heterodimer of hPcf11 and hClp1. The heterodimer is active in partially reconstituted cleavage reactions, whereas hClp1 by itself is not. Pcf11 moderately stimulates the RNA 5' kinase activity of hClp1; the kinase activity is dispensable for RNA cleavage | 30139799 |
| 2014-07-05 11:49:00 | Study reports the identification of a human CLP1 mutation that impairs tRNA splicing in vitro and causes a neurological syndrome involving both the central nervous system (CNS) and peripheral nervous system (PNS). | 24766809 |
| 2014-07-05 11:49:00 | Data link tRNA maturation to neuronal development and neurodegeneration through defective CLP1 function in humans. | 24766810 |
| 2010-01-21 00:00:00 | Expression of hClp1 in budding yeast can complement conditional and lethal mutations in the essential 5'-OH RNA kinase module of yeast or plant tRNA ligases. | 18648070 |
| 2010-01-21 00:00:00 | the kinase hClp1 phosphorylates and licenses synthetic siRNAs to become assembled into RISC for subsequent target RNA cleavage | 17495927 |
| Type | IDs |
|---|---|
| Synonymous | HEAB, hClp1 |
| Gene |
UniProtKB-ID:
CLP1_HUMAN
UniprotKB:
Q92989
UniParc:
UPI000012754A,
UPI00001FA787
EMBL:
AK313007,
U73524,
CH471076,
BC000446,
AK300232
Ensembl:
ENSG00000172409
KO:
hsa:10978
|
| Nucleutide sequences |
EMBL-CDS:
BAG35843.1,
AAC50780.1,
AAH00446.1,
EAW73770.1,
BAG62000.1
Ensembl_TRS:
ENST00000525602,
ENST00000302731,
ENST00000533682
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000304704,
ENSP00000434995,
ENSP00000436066
RefSeq:
NP_001136069.1,
NP_006822.1
|
| Others |
UniRef100:
UniRef100_Q92989
UniRef90:
UniRef90_Q92989
UniRef50:
UniRef50_Q92989
UniGene:
Hs.523687
CCDS:
CCDS7964.1,
CCDS44600.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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