APOBEC2 - apolipoprotein B mRNA editing enzyme catalytic subunit 2-BMKCloudï½ç¾è¿å®¢äº

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10930 APOBEC2

基因描述

Type	Description
Definition	apolipoprotein B mRNA editing enzyme catalytic subunit 2

研究结论

Date	Results	Publications
2012-06-02 11:09:00	Findings indicate that aberrant APOBEC2 expression causes nucleotide alterations in the transcripts of the specific target gene and could be involved in the development of human hepatocellular carcinoma through hepatic inflammation.	21469143
2010-05-10 12:07:00	Studies indicate the APOBEC family consists of 11 members: APOBEC-1 (Apo1), APOBEC-2 (Apo2), activation induced cytidine deaminase (AID), APOBEC- 3A, -3B, -3C, -3DE, -3F, -3H (Apo3A-H) and APOBEC- 4 (Apo4).	19911124
2010-05-03 11:06:00	The APOBEC2 was confirmed to be elevated in the tonsils with IgAN patients, and the gene expression level was negatively related with serum IgG level in overall patients.	20138841
2010-01-21 00:00:00	crystal structure of APOBEC2	17187054
2008-11-16 21:30:00	Observational study of gene-disease association. (HuGE Navigator)	18974842

名称对应

Type	IDs
Synonymous	ARCD1, ARP1
Gene	UniProtKB-ID: ABEC2_HUMAN UniprotKB: Q9Y235 UniParc: UPI000000DC55 EMBL: CH471081, AF161698, BC047767, BC069764, AK223461, AK313288, AL031778, BC069688 Ensembl: ENSG00000124701 KO: hsa:10930
Nucleutide sequences	EMBL-CDS: AAD45360.1, AAH69688.1, BAG36096.1, AAH47767.1, EAX04009.1, BAD97181.1, AAH69764.1 Ensembl_TRS: ENST00000244669
Protein sequencees	Ensembl_PRO: ENSP00000244669 RefSeq: NP_006780.1
Others	UniRef100: UniRef100_Q9Y235 UniRef90: UniRef90_Q9Y235 UniRef50: UniRef50_Q9Y235 UniGene: Hs.555915 CCDS: CCDS4848.1

全选

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mRNA

Protein

UniprotKB

Description

Refseq

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Ensembl: {{protein.nucleotideEnsembl}}

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Ensembl: {{protein.proteinEnsembl}}

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Definition: {{{protein.definition}}}

Transcript Veriant:{{protein.transcriptVeriant}}

Status: {{protein.status}}

Location

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Pubmed编号	文献信息	发表日期	相关基因
21469143	Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis. Int. J. Cancer Shunsuke Okuyama , Hiroyuki Marusawa , Tomonori Matsumoto , Yoshihide Ueda , Yuko Matsumoto , Yoko Endo , Atsushi Takai , Tsutomu Chiba	2012-03-15	Apobec2, APOBEC2
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21496894	Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell Junjie U Guo , Yijing Su , Chun Zhong , Guo-li Ming , Hongjun Song	2011-04-29	Apobec1, Tet1, APOBEC2, APOBEC3A, APOBEC3F, APOBEC3C, APEX1, AICDA, TET1
20138841	Microarray analysis of tonsils in immunoglobulin A nephropathy patients. Biochem. Biophys. Res. Commun. Kenichiro Iio , Yasuyuki Nagasawa , Hirotsugu Iwatani , Ryohei Yamamoto , Arata Horii , Daisuke Okuzaki , Yoshiyuki Furumatsu , Hidenori Inohara , Hiroshi Nojima , Enyu Imai , Yoshitaka Isaka , Hiromi Rakugi	2010-03-19	APOBEC2, CALB2
19911124	APOBEC deaminases-mutases with defensive roles for immunity. Sci. China, C, Life Sci. Courtney Prochnow , Ronda Bransteitter , XiaoJiang S Chen	2009-10-01	APOBEC2, APOBEC3A, APOBEC3C, APOBEC1, APOBEC4, AICDA, APOBEC3B
18974842	Gender differences in genetic risk profiles for cardiovascular disease. PLoS ONE Kaisa Silander , Mervi Alanne , Kati Kristiansson , Olli Saarela , Samuli Ripatti , Kirsi Auro , Juha Karvanen , Sangita Kulathinal , Matti NiemelÃ¤ , Pekka Ellonen , Erkki Vartiainen , Pekka Jousilahti , Janna Saarela , Kari Kuulasmaa , Alun Evans , Markus Perola , Veikko Salomaa , Leena Peltonen	2008-01-01	TXNIP, APOBEC2, APOA5, CPB2, CRP, ACE, AGTR1, F2, F2R, F5, F7, F10, F12, F13A1, FGA, FGB, FGG, FOXC2, LPIN1, FUT3, ICAM1, APOE, IL1A, IL1B, IL6, IL10, ITGA2, ITGB3, LCT, LMAN1, LTA, MTHFR, NPY, SERPINE1, PLAT, VIMP, PROC, SELE, SELL, SELP, THBD, TNF, USF1, VCAM1, CD14, KL
17187054	The APOBEC-2 crystal structure and functional implications for the deaminase AID. Nature Courtney Prochnow , Ronda Bransteitter , Michael G Klein , Myron F Goodman , Xiaojiang S Chen	2007-01-25	APOBEC2
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team	2004-10-01	Ldlrap1, Dnajc3, Rnaset2a, Btnl1, Isg15, Cyp3a41b, Ly6c2, Ccl21b, Eif3j2, Mup18, Lrrc19, Rcc1, 1700047I17Rik2, Pcsk9, Adat3, Tdrd7, Sco2, Gpr153, Pafah2, Gm44504, H6pd, Adprhl2, Gpn2, Rusc2, Stx12, Ppp1r8, Smpdl3b, Fam46b, Bsdc1, Slc44a1, Zfand2a, Rubcn, Kifc1, Pifo, C030017K20Rik, Cbarp, Rpl5, Micalcl, Atg14, Lrrc8c, Noc4l, Nsun5, Psph, Trrap, Mapre3, Ube3c, Tbc1d14, Hscb, Tyw1, Emilin1, Rab28, Pot1a, Parp11, Tada3, Tra2a, Brk1, Fbxl14, Phrf1, Plekha1, Gm21975, Ric8a, Mob2, Prkd2, Ccp110, Vrk3, Grwd1, Nlrp6, Trim68, Psip1, Spred3, Faap24, Ints4, Rrp8, Unc45a, Igflr1, Sf3b3, D8Ertd738e, Usb1, Champ1, Smim19, Exoc8, Gadd45gip1, Phkb, Dohh, Fam192a, Enkd1, Taf5l, Zdhhc7, Snapc2, Ak6, Gpat4, Dcun1d2, Ankrd10, Cog4, Hinfp, Lars2, Xylb, Imp3, Cmtm7
14574404	The DNA sequence and analysis of human chromosome 6. Nature A J Mungall , S A Palmer , S K Sims , C A Edwards , J L Ashurst , L Wilming , M C Jones , R Horton , S E Hunt , C E Scott , J G R Gilbert , M E Clamp , G Bethel , S Milne , R Ainscough , J P Almeida , K D Ambrose , T D Andrews , R I S Ashwell , A K Babbage , C L Bagguley , J Bailey , R Banerjee , D J Barker , K F Barlow , K Bates , D M Beare , H Beasley , O Beasley , C P Bird , S Blakey , S Bray-Allen , J Brook , A J Brown , J Y Brown , D C Burford , W Burrill , J Burton , C Carder , N P Carter , J C Chapman , S Y Clark , G Clark , C M Clee , S Clegg , V Cobley , R E Collier , J E Collins , L K Colman , N R Corby , G J Coville , K M Culley , P Dhami , J Davies , M Dunn , M E Earthrowl , A E Ellington , K A Evans , L Faulkner , M D Francis , A Frankish , J Frankland , L French , P Garner , J Garnett , M J R Ghori , L M Gilby , C J Gillson , R J Glithero , D V Grafham , M Grant , S Gribble , C Griffiths , M Griffiths , R Hall , K S Halls , S Hammond , J L Harley , E A Hart , P D Heath , R Heathcott , S J Holmes , P J Howden , K L Howe , G R Howell , E Huckle , S J Humphray , M D Humphries , A R Hunt , C M Johnson , A A Joy , M Kay , S J Keenan , A M Kimberley , A King , G K Laird , C Langford , S Lawlor , D A Leongamornlert , M Leversha , C R Lloyd , D M Lloyd , J E Loveland , J Lovell , S Martin , M Mashreghi-Mohammadi , G L Maslen , L Matthews , O T McCann , S J McLaren , K McLay , A McMurray , M J F Moore , J C Mullikin , D Niblett , T Nickerson , K L Novik , K Oliver , E K Overton-Larty , A Parker , R Patel , A V Pearce , A I Peck , B Phillimore , S Phillips , R W Plumb , K M Porter , Y Ramsey , S A Ranby , C M Rice , M T Ross , S M Searle , H K Sehra , E Sheridan , C D Skuce , S Smith , M Smith , L Spraggon , S L Squares , C A Steward , N Sycamore , G Tamlyn-Hall , J Tester , A J Theaker , D W Thomas , A Thorpe , A Tracey , A Tromans , B Tubby , M Wall , J M Wallis , A P West , S S White , S L Whitehead , H Whittaker , A Wild , D J Willey , T E Wilmer , J M Wood , P W Wray , J C Wyatt , L Young , R M Younger , D R Bentley , A Coulson , R Durbin , T Hubbard , J E Sulston , I Dunham , J Rogers , S Beck	2003-10-23	GJE1, SMIM11P1, TRAPPC3L, C6orf99, TOMM6, HSPD1P16, MTRNR2L9, RANBP9, LOC100505530, KIF25-AS1, MICA, UST, LOC100996634, MEI4, SLC17A2, CDKN1A, PRSS16, CRISP3, BTN3A3, BTN2A2, ECI2, HMGN4, SYNCRIP, UBD, AGPAT1, SLC35A1, SCGN, DNPH1, C6orf10, FARS2, FUT9, TBC1D7-LOC100130357, TRAF3IP2, HBS1L, FRS3, PDE10A, SMPDL3A, APOBEC2, PNRC1, RAB32, TRIM31, KATNA1, FGFR1OP, BTN3A2, BTN3A1, BTN2A1, NUDT3, MRAP2, RWDD2A, IL17F, MTFR2, STK38, SFT2D1, EFHC1, ZBED9, MB21D1, KLHDC3, NUS1, GINM1, IL22RA2, MAS1L, TAGAP, CLIC1, CCR6, CNR1, COL9A1, COL10A1, COL11A2, COL19A1, COX7A2, TAAR1, STXBP5, NCOA7, PACRG, B3GAT2, SDHAF4, CD109, RAET1E, C6orf141, HUS1B, ATF6B, NRSN1, MAPK14, CSNK2B, CTGF, ZC2HC1B, SNRNP48, MBOAT1, RNF217, NKAIN2, CFAP206, LINC01600, BVES-AS1, CYP21A1P, DAXX, CRISP1, LCA5, OLIG3, TXLNB
12683974	Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business. Trends Genet. Joseph E Wedekind , Geoffrey S C Dance , Mark P Sowden , Harold C Smith	2003-04-01	-

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