| Type | Description |
|---|---|
| Definition | sphingomyelin phosphodiesterase acid like 3A |
| Date | Results | Publications |
|---|---|---|
| 2017-06-24 11:26:00 | Activation of pregnane X receptor induces SMPDL3A expression in primary hepatocytes. | 28414139 |
| 2017-06-24 11:14:00 | Site-specific N-glycosylation is essential for the intracellular stability, secretion and activity of human SMPDL3A. | 28104755 |
| 2016-08-06 10:40:00 | Solved the structure of SMPDL3a revealing a calcineurin-like fold. A dimetal site, glycosylation pattern and a disulfide bond network are likely to be conserved also in aSMase. We show that the binuclear site of SMPDL3a is occupied by two Zn(2+) ions. | 26783088 |
| 2015-02-14 14:06:00 | Data indicate that sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a nucleotide phosphodiesterase secreted from cholesterol-loaded macrophages. | 25288789 |
| 2012-12-22 10:09:00 | the induction of SMPDL3A is liver X receptor-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. | 22810003 |
| Type | IDs |
|---|---|
| Synonymous | ASM3A, ASML3a, yR36GH4.1 |
| Gene |
UniProtKB-ID:
ASM3A_HUMAN
UniprotKB:
Q92484
UniParc:
UPI0000EE1F31,
UPI00000701D1
EMBL:
CH471051,
AK301365,
BC018999,
AL732431,
Y08136
Ensembl:
ENSG00000172594
KO:
hsa:10924
|
| Nucleutide sequences |
EMBL-CDS:
CAA69330.1,
AAH18999.1,
BAH13465.1,
EAW48164.1
Ensembl_TRS:
ENST00000368440,
ENST00000539041
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000357425,
ENSP00000442152
RefSeq:
XP_005266859.1,
NP_006705.1,
NP_001273067.1,
XP_005266854.1,
XP_005266858.1,
XP_005266856.1,
XP_016865692.1,
XP_016865693.1,
XP_005266855.1
|
| Others |
UniRef100:
UniRef100_Q92484
UniRef90:
UniRef90_Q92484
UniRef50:
UniRef50_Q92484
UniGene:
Hs.486357
CCDS:
CCDS69190.1,
CCDS5128.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 28414139 |
Biochem. Pharmacol. Judith Jeske , Andreas Bitter , Wolfgang E Thasler , Thomas S Weiss , Matthias Schwab , Oliver Burk |
2017-07-15 | - |
| 28104755 |
Biochem. J. Mathew Traini , Raani Kumaran , Morten Thaysen-Andersen , Maaike Kockx , Wendy Jessup , Leonard Kritharides |
2017-03-08 | - |
| 26783088 |
FEBS J. Sing Mei Lim , Kit Yeung , Lionel Trésaugues , Teo Hsiang Ling , Pär Nordlund |
2016-03-01 |
SMPDL3A
|
| 25288789 |
J. Biol. Chem. Mathew Traini , Carmel M Quinn , Cecilia Sandoval , Erik Johansson , Kate Schroder , Maaike Kockx , Peter J Meikle , Wendy Jessup , Leonard Kritharides |
2014-11-21 |
Smpdl3a,
SMPDL3A
|
| 23533145 |
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics Simona Principe , E Ellen Jones , Yunee Kim , Ankit Sinha , Julius O Nyalwidhe , Jasmin Brooks , O John Semmes , Dean A Troyer , Raymond S Lance , Thomas Kislinger , Richard R Drake |
2013-05-01 | - |
| 22810003 |
Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors. Mol. Pharmacol. Paul B Noto , Yuri Bukhtiyarov , Meng Shi , Brian M McKeever , Gerard M McGeehan , Deepak S Lala |
2012-10-01 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 16344560 |
Genome Res. Kouichi Kimura , Ai Wakamatsu , Yutaka Suzuki , Toshio Ota , Tetsuo Nishikawa , Riu Yamashita , Jun-ichi Yamamoto , Mitsuo Sekine , Katsuki Tsuritani , Hiroyuki Wakaguri , Shizuko Ishii , Tomoyasu Sugiyama , Kaoru Saito , Yuko Isono , Ryotaro Irie , Norihiro Kushida , Takahiro Yoneyama , Rie Otsuka , Katsuhiro Kanda , Takahide Yokoi , Hiroshi Kondo , Masako Wagatsuma , Katsuji Murakawa , Shinichi Ishida , Tadashi Ishibashi , Asako Takahashi-Fujii , Tomoo Tanase , Keiichi Nagai , Hisashi Kikuchi , Kenta Nakai , Takao Isogai , Sumio Sugano |
2006-01-01 |
Nefm,
MED6,
CDH2,
PDZK1P1,
DDTL,
ABI1,
GNPDA1,
GTF2IP4,
ZSCAN30,
SRA1,
TMEM170B,
HOTAIR,
FAM86JP,
LOC100126784,
C8orf88,
LOC100128006,
RAB28P5,
MYHAS,
CDC42P3,
LOC100128979,
LOC100128993,
KTN1-AS1,
LOC100129083,
LOC100129204,
TOPORS-AS1,
LINC00484,
ZNF37BP,
FAM47E,
MRVI1-AS1,
ZNF737,
LOC100130075,
MAPT-IT1,
MIR124-2HG,
LINC00861,
LOC100130238,
LOC100130357,
PARD6G-AS1,
LOC100130547,
NFYC-AS1,
EFCAB10,
LOC100130798,
SBK3,
LOC100130849,
LOC100130872,
LOC100130880,
LOC100130987,
LOC100131047,
LINC01135,
CKMT2-AS1,
ZBTB20-AS1,
WDR86-AS1,
CCDC183-AS1,
SNAP25-AS1,
NEMP2,
ZNF503-AS2,
MIR181A1HG,
DBIL5P,
HDAC6,
MZF1-AS1,
ARMCX4,
LINC00271,
ZNF717,
LOC100132057,
LOC100132111,
CALML3-AS1,
NDUFA6-AS1,
FRG1HP,
FCGR1CP,
GXYLT1P3,
GOLGA8F,
DCAF13P3,
IPO5P1,
MSC-AS1,
SMIM9,
FAM66A,
CD24,
UXT-AS1,
JHDM1D-AS1,
UBE2Q2P2,
TEN1,
JMJD7,
PLA2G4B,
LINC00930,
PDCD6IP,
HECTD2-AS1,
ZFHX4-AS1,
FAR2P2,
LOC100233156,
PCED1B-AS1,
PIGK,
LOC100270746,
LOC100270804,
LINC00940,
ERVV-2,
MEF2B,
ZNRF2P2,
NFE2L3P2,
LINC00894,
BCDIN3D-AS1
|
| 15489334 |
Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team |
2004-10-01 |
Ldlrap1,
Dnajc3,
Rnaset2a,
Btnl1,
Isg15,
Cyp3a41b,
Ly6c2,
Ccl21b,
Eif3j2,
Mup18,
Lrrc19,
Rcc1,
1700047I17Rik2,
Pcsk9,
Adat3,
Tdrd7,
Sco2,
Gpr153,
Pafah2,
Gm44504,
H6pd,
Adprhl2,
Gpn2,
Rusc2,
Stx12,
Ppp1r8,
Smpdl3b,
Fam46b,
Bsdc1,
Slc44a1,
Zfand2a,
Rubcn,
Kifc1,
Pifo,
C030017K20Rik,
Cbarp,
Rpl5,
Micalcl,
Atg14,
Lrrc8c,
Noc4l,
Nsun5,
Psph,
Trrap,
Mapre3,
Ube3c,
Tbc1d14,
Hscb,
Tyw1,
Emilin1,
Rab28,
Pot1a,
Parp11,
Tada3,
Tra2a,
Brk1,
Fbxl14,
Phrf1,
Plekha1,
Gm21975,
Ric8a,
Mob2,
Prkd2,
Ccp110,
Vrk3,
Grwd1,
Nlrp6,
Trim68,
Psip1,
Spred3,
Faap24,
Ints4,
Rrp8,
Unc45a,
Igflr1,
Sf3b3,
D8Ertd738e,
Usb1,
Champ1,
Smim19,
Exoc8,
Gadd45gip1,
Phkb,
Dohh,
Fam192a,
Enkd1,
Taf5l,
Zdhhc7,
Snapc2,
Ak6,
Gpat4,
Dcun1d2,
Ankrd10,
Cog4,
Hinfp,
Lars2,
Xylb,
Imp3,
Cmtm7
|
| 15174051 |
An investigation into the human serum "interactome". Electrophoresis Ming Zhou , David A Lucas , King C Chan , Haleem J Issaq , Emanuel F Petricoin , Lance A Liotta , Timothy D Veenstra , Thomas P Conrads |
2004-05-01 |
ERVK-10,
SLC25A13,
SORBS3,
SMPDL3A,
GCN1,
LECT1,
LDB3,
CHKB,
DCD,
CLU,
FAM83C,
CP,
CST3,
ADRA1B,
SGO2,
CTSL,
PRSS3P2,
DGKG,
DCC,
DDB1,
CFD,
AGA,
DMD,
DNTT,
AHSG,
ETF1,
ALB,
F2,
F7,
FGA,
NLRP1,
CNOT1,
ZNF292,
SETX,
RRP1B,
CAMTA1,
SLC9A8,
FN1,
OBSL1,
DICER1,
CRB1,
AP4E1,
ABCA6,
OR2T6,
GABBR1,
PLA2G4F,
FAM169A,
SPATA31A7,
SACS,
GDF10,
GFAP,
LAT,
BBC3,
AMPD3,
OR8D2,
FAM71E2,
IGKV2-40,
GSN,
SERTAD3,
PDZRN4,
HBA1,
HBA2,
CFH,
HP,
HPX,
APOA1,
APOA2,
APOA4,
APOC1,
APOC2,
APOC3,
APOE,
IGHG1,
IGHG2,
IGKC,
IGL,
IGLC1,
KLK3,
ITGA2,
ITGB5,
ITIH1,
JARID2,
KCNMA1,
KRT1,
KRT5,
KRT6A,
KRT6B,
KRT9,
KRT10,
KRT13,
KRT14,
KRT16,
CTAGE5,
MYL4,
ATM,
NPHS1,
OR3A2,
PCDH1,
PDE4B
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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目前还没有研究热点人员