| Type | Description |
|---|---|
| Definition | adenylate cyclase 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-18 11:00:00 | ADCY3 is an important mediator of energy homeostasis and an attractive pharmacological target in the treatment of obesity. | 29311637 |
| 2019-05-18 10:21:00 | An enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts. | 29311636 |
| 2019-05-18 10:21:00 | MC4R colocalizes with ADCY3 at the primary cilia of a subset of hypothalamic neurons; obesity-associated MC4R mutations impair ciliary localization and inhibition of adenylyl cyclase signaling at the primary cilia of these neurons increases body weight. | 29311635 |
| 2018-10-27 10:29:00 | This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet. | 29921800 |
| 2017-08-12 10:26:00 | In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops. | 28122017 |
| Type | IDs |
|---|---|
| Synonymous | AC-III, AC3, BMIQ19 |
| Gene |
UniProtKB-ID:
ADCY3_HUMAN,
A0A0A0MSC1_HUMAN,
B7ZLX9_HUMAN
UniprotKB:
O60266,
A0A0A0MSC1,
B7ZLX9
UniParc:
UPI000013D0ED,
UPI00003E5E71,
UPI000189A8BB,
UPI000387D86B
EMBL:
AF033861,
AC012073,
AB011083,
BC126235,
BC144119,
AK095173
Ensembl:
ENSG00000138031
KO:
hsa:109
|
| Nucleutide sequences |
EMBL-CDS:
AAI26236.1,
AAY14787.1,
BAA25437.1,
AAD13403.1,
BAG52998.1,
AAI44120.1
Ensembl_TRS:
ENST00000260600,
ENST00000405392
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000260600,
ENSP00000384484
RefSeq:
XP_011530792.1,
NP_004027.2,
XP_011530798.1,
XP_011530795.1,
XP_011530793.1,
NP_001364061.1,
XP_016858678.1,
XP_011530791.1,
NP_001307542.1,
NP_001364058.1,
NP_001364060.1,
XP_016858681.1,
NP_001364057.1,
XP_006711988.1,
XP_011530794.1,
NP_001364059.1,
XP_016858680.1,
XP_011530796.1,
XP_016858677.1,
XP_016858676.1
|
| Others |
UniRef100:
UniRef100_O60266,
UniRef100_A0A0A0MSC1,
UniRef100_B7ZLX9
UniRef90:
UniRef90_Q8VHH7
UniRef50:
UniRef50_Q8VHH7
UniGene:
Hs.467898
CCDS:
CCDS1715.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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