| Type | Description |
|---|---|
| Definition | caspase recruitment domain family, member 11 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 13:00:00 | Caspase-11 contributes to pulmonary host defense against Klebsiella pneumoniae and local activation of coagulation. | 32401674 |
| 2020-08-01 10:50:00 | The role of CARD11 is further revealed by the effects of pathogenic CARD11 mutants on this noncanonical regulatory function on the AKT-FOXO1 signaling axis. | 31784498 |
| 2020-05-09 12:06:00 | Three distinct single nucleotide variants were found in the Card11 introns 2, 10 and 20 that cause the loss of CARD11 expression in lack of costimulation (loco) mutant mice. These mutations caused the loss of thymic-derived, Neuropilin-1+ (NRP1+) Treg cells in neonatal and adult loco mice; however, residual peripherally induced NRP1- Treg cells remained, suggesting that CARD11 is dispensable for Treg cell function. | 31087793 |
| 2019-09-21 10:49:00 | results demonstrate that partial disruption of the CBM complex and induction of IFNgamma secretion in the preferentially self-reactive Treg cell pool does not cause systemic autoimmunity but is sufficient to prime the tumour environment for successful immune checkpoint therapy | 31092922 |
| 2019-09-07 12:05:00 | aCard11 GC B cells displayed increased biomass and mTORC1 signaling, suggesting a novel strategy for targeting aCARD11-driven DLBCL. While aCARD11 potently impacts GC responses, the rapid GC contraction suggests it requires collaboration with events that limit terminal differentiation to promote lymphoma. | 30127060 |
| Type | IDs |
|---|---|
| Synonymous | 0610008L17Rik, 2410011D02Rik, BIMP3, CARMA1 |
| Gene |
UniProtKB-ID:
CAR11_MOUSE
UniprotKB:
Q8CIS0
UniParc:
UPI00015DF1C9,
UPI000024E328
EMBL:
BC096592,
AY135367,
AK037968,
AK131134
Ensembl:
ENSMUSG00000036526
KO:
mmu:108723
|
| Nucleutide sequences |
EMBL-CDS:
BAC29910.1,
AAH96592.1,
BAD21384.1,
AAN10150.1
Ensembl_TRS:
ENSMUST00000085786
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000082941
RefSeq:
NP_780571.2
|
| Others |
UniRef100:
UniRef100_Q8CIS0
UniRef90:
UniRef90_Q8CIS0
UniRef50:
UniRef50_Q9BXL7
UniGene:
Mm.46187
CCDS:
CCDS51686.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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