PDE10A - phosphodiesterase 10A-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

收藏

10846 PDE10A

基因描述

Type	Description
Definition	phosphodiesterase 10A

研究结论

Date	Results	Publications
2020-05-09 10:17:00	Mutations in the regulatory GAF domains of PDE10A that cause hyperkinetic syndromes in humans lead to misprocessing of the PDE10A enzyme that ultimately leads to targeted degradation by the ubiquitin proteasome system or clearance by autophagy. Both mechanisms result in a paucity of PDE10A activity that lead to a loss of movement coordination.	31871190
2020-02-08 10:21:00	PDE10A IgG defines a novel rare neurologic autoimmune syndrome and expands the spectrum of diagnosable paraneoplastic CNS disorders.	31315972
2019-09-14 10:37:00	indicate an association between PDE10A and ADCY5 mutations and pre/postsynaptic molecular changes, substantia nigra damage, and white and gray matter changes within the striatocortical pathways	30345538
2019-05-04 10:10:00	This report that PDE10A mutation is associated with familial Benign hereditary chorea.	29165877
2019-02-16 10:51:00	natural selection on genetic variants in the PDE10A gene have increased spleen size in the Bajau population of Indonesia, providing them with a larger reservoir of oxygenated red blood cells	29677510

名称对应

Type	IDs
Synonymous	ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19
Gene	UniProtKB-ID: PDE10_HUMAN, A0A1B1UZQ1_HUMAN, A0A1B1UZR0_HUMAN UniprotKB: Q9Y233, A0A1B1UZQ1, A0A1B1UZR0 UniParc: UPI0000039E34, UPI0000E0A69C, UPI000006F80E EMBL: AL117345, KU519418, AB026816, KF458359, AL160160, AL590302, KU519416, KU519415, KU519407, BC104858, AF127480, AB041798, AL591962, CR536567, AL136130, BC104860, KF458352, KU519409, KU519412, KU519413, KU519414, AF127479, CH471051, AB020593, AL121789 Ensembl: ENSG00000112541 KO: hsa:10846
Nucleutide sequences	EMBL-CDS: AAI04861.1, AAD32596.1, AAD32595.1, CAG38804.1, BAA84467.1, AAI04859.1, BAB16383.1, BAA78034.1, ANW09721.1, ANW09718.1, ANW09713.1, ANW09722.1, ANW09719.1, ANW09715.1, ANW09724.1, ANW09720.1, EAW47546.1 Gene_ORFName: hCG_34059 Ensembl_TRS: ENST00000366882, ENST00000648884
Protein sequencees	Ensembl_PRO: ENSP00000355847, ENSP00000497392 RefSeq: XP_024302080.1, XP_011533689.2, XP_024302079.1, XP_016865686.1, XP_016865684.1, XP_011533695.1, XP_016865683.1, NP_006652.1, XP_006715384.1, NP_001372008.1, XP_011533690.1, XP_016865685.1, NP_001124162.1
Others	UniRef100: UniRef100_Q9Y233, UniRef100_A0A3F2YP58 UniRef90: UniRef90_A0A5F7ZC47, UniRef90_Q9Y233 UniRef50: UniRef50_Q9Y233, UniRef50_A0A5F7ZC47 UniGene: Hs.348762 CCDS: CCDS5289.1, CCDS47513.1

全选

{{proteinIndex+1}}

mRNA

Protein

UniprotKB

Description

Refseq

{{protein.nucleotideVersion}}

Ensembl: {{protein.nucleotideEnsembl}}

{{protein.proteinVersion}}

Ensembl: {{protein.proteinEnsembl}}

{{uniprot}}

Definition: {{{protein.definition}}}

Transcript Veriant:{{protein.transcriptVeriant}}

Status: {{protein.status}}

Location

( {{protein.positionStart}}..{{protein.positionEnd}} )

暂无数据

收藏到我的文献

全选

Pubmed编号	文献信息	发表日期	相关基因
31871190	Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme. Proc Natl Acad Sci U S A Gonzalo S Tejeda , Ellanor L Whiteley , Tarek Z Deeb , Roland W BÃ¼rli , Stephen J Moss , Eamonn Sheridan , Nicholas J Brandon , George S Baillie	2020-01-07	-
31315972	Phosphodiesterase 10A IgG: A novel biomarker of paraneoplastic neurologic autoimmunity. Neurology Anastasia Zekeridou , Thomas Kryzer , Yong Guo , Anhar Hassan , Vanda Lennon , Claudia F Lucchinetti , Sean Pittock , Andrew McKeon	2019-08-20	-
30345538	PDE10A and ADCY5 mutations linked to molecular and microstructural basal ganglia pathology. Mov. Disord. Flavia Niccolini , Niccolo E Mencacci , Tayyabah Yousaf , Eugenii A Rabiner , Vincenzo Salpietro , Gennaro Pagano , Bettina Balint , Stephanie Efthymiou , Henry Houlden , Roger N Gunn , Nicholas Wood , Kailash P Bhatia , Marios Politis	2018-12-01	-
29987050	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Proc. Natl. Acad. Sci. U.S.A. Tengfei Xiao , Wei Li , Xiaoqing Wang , Han Xu , Jixin Yang , Qiu Wu , Ying Huang , Joseph Geradts , Peng Jiang , Teng Fei , David Chi , Chongzhi Zang , Qi Liao , Jonathan Rennhack , Eran Andrechek , Nanlin Li , Simone Detre , Mitchell Dowsett , Rinath M Jeselsohn , X Shirley Liu , Myles Brown	2018-07-31	-
29677510	Physiological and Genetic Adaptations to Diving in Sea Nomads. Cell Melissa A Ilardo , Ida Moltke , Thorfinn S Korneliussen , Jade Cheng , Aaron J Stern , Fernando Racimo , Peter de Barros Damgaard , Martin Sikora , Andaine Seguin-Orlando , Simon Rasmussen , Inge C L van den Munckhof , Rob Ter Horst , Leo A B Joosten , Mihai G Netea , Suhartini Salingkat , Rasmus Nielsen , Eske Willerslev	2018-04-19	-
29165877	A familial case of PDE10A-associated childhood-onset chorea with bilateral striatal lesions. Mov. Disord. Satoko Miyatake , Eriko Koshimizu , Ikuko Shirai , Satoko Kumada , Yasuhiro Nakata , Aiko Kamemaru , Mitsuko Nakashima , Takeshi Mizuguchi , Noriko Miyake , Hirotomo Saitsu , Naomichi Matsumoto	2018-01-01	-
29130591	Familial choreoathetosis due to novel heterozygous mutation in PDE10A. Am J Med Genet A Dhanya L Narayanan , Dipti Deshpande , Aneek Das Bhowmik , Dandu R Varma , Ashwin Dalal	2018-01-01	-
28727628	Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS). Pharmacogenet. Genomics Enrique Soto-Pedre , Moneeza K Siddiqui , Alex S Doney , Colin N A Palmer , Ewan R Pearson , Graham P Leese	2017-10-01	-
28611215	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proc. Natl. Acad. Sci. U.S.A. Teng Fei , Yiwen Chen , Tengfei Xiao , Wei Li , Laura Cato , Peng Zhang , Maura B Cotter , Michaela Bowden , Rosina T Lis , Shuang G Zhao , Qiu Wu , Felix Y Feng , Massimo Loda , Housheng Hansen He , X Shirley Liu , Myles Brown	2017-06-27	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-

研究热度

热点单位

排名	科研单位	文献
{{affIndex+1}}	{{aff.value}}	{{aff.size}}

目前还没有研究热点单位

热点人员

排名	研究人员	文献
{{authorIndex+1}}	{{author.value}}	{{author.size}}

目前还没有研究热点人员

© 2017 biocloud.net版权所有 ICP证：京10042835号