| Type | Description |
|---|---|
| Definition | caseinolytic mitochondrial matrix peptidase chaperone subunit |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:30:00 | Experiencing community and domestic violence is associated with epigenetic changes in DNA methylation of BDNF and CLPX in adolescents. | 31059136 |
| 2018-06-09 12:20:00 | The mutation in CLPX inactivates its ATPase activity, resulting in coassembly of mutant and WT protomers to form an enzyme with reduced activity. The presence of low-activity CLPX increases the posttranslational stability of ALAS, causing increased ALAS protein and ALA levels, leading to abnormal accumulation of PPIX. | 28874591 |
| 2017-06-24 12:45:00 | Data suggest that tumors exploit ClpXP-directed proteostasis to maintain mitochondrial bioenergetics, buffer oxidative stress, and enable metastatic competence. | 27389535 |
| 2015-12-05 10:13:00 | results illustrate that ClpX overexpression is a good and simple model to study the underlying mechanisms of the UPRmt in mammalian cells. | 26142927 |
| 2015-02-07 12:41:00 | Optical trapping to assay single-molecule ClpXP unfolding and translocation of substrates consisting of domains with varying stabilities and sequences; find that ClpXP unfolds most domains by a single pathway, with kinetics that depend on the native fold and structural stability. | 25083874 |
| Type | IDs |
|---|---|
| Synonymous | EPP2 |
| Gene |
UniProtKB-ID:
CLPX_HUMAN,
A0A024R5X7_HUMAN
UniprotKB:
O76031,
A0A024R5X7
UniParc:
UPI0000127B73
EMBL:
AJ276966,
AJ276968,
AJ006267,
AJ276972,
CH471082,
AK292316,
AJ276976,
AJ276971,
AJ276973,
AJ276967,
AJ276980,
AJ276974,
AJ276977,
AJ276969,
AJ276981,
AJ276975,
AJ276970,
BC130373,
BC136487
Ensembl:
ENSG00000166855
KO:
hsa:10845
|
| Nucleutide sequences |
EMBL-CDS:
AAI36488.1,
EAW77715.1,
CAA06933.2,
BAF85005.1,
AAI30374.1,
CAC01291.1,
EAW77716.1
Gene_ORFName:
hCG_23663
Ensembl_TRS:
ENST00000300107
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000300107
RefSeq:
NP_006651.2,
XP_011519466.1
|
| Others |
UniRef100:
UniRef100_O76031
UniRef90:
UniRef90_O76031
UniRef50:
UniRef50_O76031
UniGene:
Hs.113823
CCDS:
CCDS10202.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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