| Type | Description |
|---|---|
| Definition | fibroblast growth factor receptor substrate 3 |
| Date | Results | Publications |
|---|---|---|
| 2013-07-10 09:55:00 | Mechanisms by which FRS2beta acts as a feedback inhibitor of EGFR family members and suggest a role for FRS2beta as a tumor suppressor. | 20228838 |
| 2013-04-27 11:50:00 | an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate ErbB2 protein levels in physiological and pathological settings | 23279575 |
| 2010-01-21 00:00:00 | FRS2beta can compensate for the loss of FRS2alpha for activation of MAP kinase when expressed in fibroblasts | 15094036 |
| 2010-01-21 00:00:00 | SNT-2 negatively regulates ERK2 signaling activated via EGF stimulation through direct binding to ERK2 | 15485655 |
| 2010-01-21 00:00:00 | Novel mechanism of negative control of EGFR tyrosine kinase activity with SNT-2 by recruiting ERK2. | 16702953 |
| Type | IDs |
|---|---|
| Synonymous | FRS2-beta, FRS2B, FRS2beta, SNT-2, SNT2 |
| Gene |
UniProtKB-ID:
FRS3_HUMAN,
A0A140VJJ7_HUMAN
UniprotKB:
O43559,
A0A140VJJ7
UniParc:
UPI0000073ACA
EMBL:
BC010611,
CH471081,
AL365205,
AF036718,
HM005384,
CR457026
Ensembl:
ENSG00000137218
KO:
hsa:10817
|
| Nucleutide sequences |
EMBL-CDS:
AAH10611.1,
AAB92555.1,
CAG33307.1,
EAX04060.1,
AEE60984.1
Gene_ORFName:
hCG_1779355
Ensembl_TRS:
ENST00000373018,
ENST00000259748
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000259748,
ENSP00000362109
RefSeq:
XP_011512557.1,
XP_011512556.1,
NP_006644.1,
XP_016865682.1
|
| Others |
UniRef100:
UniRef100_O43559
UniRef90:
UniRef90_O43559
UniRef50:
UniRef50_O43559
UniGene:
Hs.194208
CCDS:
CCDS4860.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 25814554 |
Phospho-tyrosine dependent protein-protein interaction network. Mol. Syst. Biol. Arndt Grossmann , Nouhad Benlasfer , Petra Birth , Anna Hegele , Franziska Wachsmuth , Luise Apelt , Ulrich Stelzl |
2015-03-01 |
SH2B3,
SH2D3A,
HUWE1,
FSBP,
TSPAN2,
TNK2,
SPRY2,
APBB3,
TRDN,
ANAPC10,
BAIAP2,
ZNHIT1,
SEMA4D,
UBD,
CENPB,
POLR3F,
RAI2,
SDCCAG8,
FRS3,
FRS2,
PGRMC1,
CYP46A1,
ARID5A,
NMU,
RALBP1,
YWHAQ,
LECT1,
CYB561D2,
RCAN3,
CAPN10,
FSTL1,
RASSF1,
CHN2,
TP53RK,
EFHC1,
OSBPL6,
C1QTNF3,
DDIT4L,
FAM46B,
CKM,
TM4SF19,
RBP7,
OLIG1,
CLNK,
SH2D1B,
TWIST2,
ASCL4,
SOCS4,
COX6B2,
GABPB2,
SHE,
VSTM2L,
C22orf39,
PPP1R21,
SCLT1,
PACRGL,
SETD9,
C6orf141,
MAGEC3,
DCAF12L1,
CRK,
CRKL,
CRP,
TCP10L,
ASB8,
ASB9,
CRYBA2,
CSK,
DUSP18,
FAM117B,
PLB1,
IQUB,
WBSCR27,
CYP2C8,
DBN1,
PAQR7,
DDX5,
LIX1,
GLIS3,
DOK1,
EPYC,
DTNA,
E2F2,
E2F6,
PHC2,
KRTCAP2,
ELK1,
ADCK5,
EPS8,
AKT1,
ESD,
MECOM,
EYA3,
EZH2,
FABP7,
FANCG,
MPEG1,
LNX2,
FAM217A
|
| 25416956 |
A proteome-scale map of the human interactome network. Cell Thomas Rolland , Murat TaÅan , Benoit Charloteaux , Samuel J Pevzner , Quan Zhong , Nidhi Sahni , Song Yi , Irma Lemmens , Celia Fontanillo , Roberto Mosca , Atanas Kamburov , Susan D Ghiassian , Xinping Yang , Lila Ghamsari , Dawit Balcha , Bridget E Begg , Pascal Braun , Marc Brehme , Martin P Broly , Anne-Ruxandra Carvunis , Dan Convery-Zupan , Roser Corominas , Jasmin Coulombe-Huntington , Elizabeth Dann , Matija Dreze , Amélie Dricot , Changyu Fan , Eric Franzosa , Fana Gebreab , Bryan J Gutierrez , Madeleine F Hardy , Mike Jin , Shuli Kang , Ruth Kiros , Guan Ning Lin , Katja Luck , Andrew MacWilliams , Jörg Menche , Ryan R Murray , Alexandre Palagi , Matthew M Poulin , Xavier Rambout , John Rasla , Patrick Reichert , Viviana Romero , Elien Ruyssinck , Julie M Sahalie , Annemarie Scholz , Akash A Shah , Amitabh Sharma , Yun Shen , Kerstin Spirohn , Stanley Tam , Alexander O Tejeda , Shelly A Trigg , Jean-Claude Twizere , Kerwin Vega , Jennifer Walsh , Michael E Cusick , Yu Xia , Albert-László Barabási , Lilia M Iakoucheva , Patrick Aloy , Javier De Las Rivas , Jan Tavernier , Michael A Calderwood , David E Hill , Tong Hao , Frederick P Roth , Marc Vidal |
2014-11-20 | - |
| 25231870 |
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature John Rb Perry , Felix Day , Cathy E Elks , Patrick Sulem , Deborah J Thompson , Teresa Ferreira , Chunyan He , Daniel I Chasman , Tõnu Esko , Gudmar Thorleifsson , Eva Albrecht , Wei Q Ang , Tanguy Corre , Diana L Cousminer , Bjarke Feenstra , Nora Franceschini , Andrea Ganna , Andrew D Johnson , Sanela Kjellqvist , Kathryn L Lunetta , George McMahon , Ilja M Nolte , Lavinia Paternoster , Eleonora Porcu , Albert V Smith , Lisette Stolk , Alexander Teumer , Natalia TÅ¡ernikova , Emmi Tikkanen , Sheila Ulivi , Erin K Wagner , Najaf Amin , Laura J Bierut , Enda M Byrne , Jouke-Jan Hottenga , Daniel L Koller , Massimo Mangino , Tune H Pers , Laura M Yerges-Armstrong , Jing Hua Zhao , Irene L Andrulis , Hoda Anton-Culver , Femke Atsma , Stefania Bandinelli , Matthias W Beckmann , Javier Benitez , Carl Blomqvist , Stig E Bojesen , Manjeet K Bolla , Bernardo Bonanni , Hiltrud Brauch , Hermann Brenner , Julie E Buring , Jenny Chang-Claude , Stephen Chanock , Jinhui Chen , Georgia Chenevix-Trench , J Margriet Collée , Fergus J Couch , David Couper , Andrea D Coveillo , Angela Cox , Kamila Czene , Adamo Pio D'adamo , George Davey Smith , Immaculata De Vivo , Ellen W Demerath , Joe Dennis , Peter Devilee , Aida K Dieffenbach , Alison M Dunning , Gudny Eiriksdottir , Johan G Eriksson , Peter A Fasching , Luigi Ferrucci , Dieter Flesch-Janys , Henrik Flyger , Tatiana Foroud , Lude Franke , Melissa E Garcia , Montserrat GarcÃa-Closas , Frank Geller , Eco Ej de Geus , Graham G Giles , Daniel F Gudbjartsson , Vilmundur Gudnason , Pascal Guénel , Suiqun Guo , Per Hall , Ute Hamann , Robin Haring , Catharina A Hartman , Andrew C Heath , Albert Hofman , Maartje J Hooning , John L Hopper , Frank B Hu , David J Hunter , David Karasik , Douglas P Kiel , Julia A Knight , Veli-Matti Kosma , Zoltan Kutalik , Sandra Lai , Diether Lambrechts , Annika Lindblom , Reedik Mägi , Patrik K Magnusson , Arto Mannermaa , Nicholas G Martin , Gisli Masson , Patrick F McArdle , Wendy L McArdle , Mads Melbye , Kyriaki Michailidou , Evelin Mihailov , Lili Milani , Roger L Milne , Heli Nevanlinna , Patrick Neven , Ellen A Nohr , Albertine J Oldehinkel , Ben A Oostra , Aarno Palotie , Munro Peacock , Nancy L Pedersen , Paolo Peterlongo , Julian Peto , Paul Dp Pharoah , Dirkje S Postma , Anneli Pouta , Katri Pylkäs , Paolo Radice , Susan Ring , Fernando Rivadeneira , Antonietta Robino , Lynda M Rose , Anja Rudolph , Veikko Salomaa , Serena Sanna , David Schlessinger , Marjanka K Schmidt , Mellissa C Southey , Ulla Sovio , Meir J Stampfer , Doris Stöckl , Anna M Storniolo , Nicholas J Timpson , Jonathan Tyrer , Jenny A Visser , Peter Vollenweider , Henry Völzke , Gerard Waeber , Melanie Waldenberger , Henri Wallaschofski , Qin Wang , Gonneke Willemsen , Robert Winqvist , Bruce Hr Wolffenbuttel , Margaret J Wright , Australian Ovarian Cancer Study , GENICA Network , kConFab , LifeLines Cohort Study , InterAct Consortium , Early Growth Genetics (EGG) Consortium , Dorret I Boomsma , Michael J Econs , Kay-Tee Khaw , Ruth Jf Loos , Mark I McCarthy , Grant W Montgomery , John P Rice , Elizabeth A Streeten , Unnur Thorsteinsdottir , Cornelia M van Duijn , Behrooz Z Alizadeh , Sven Bergmann , Eric Boerwinkle , Heather A Boyd , Laura Crisponi , Paolo Gasparini , Christian Gieger , Tamara B Harris , Erik Ingelsson , Marjo-Riitta Järvelin , Peter Kraft , Debbie Lawlor , Andres Metspalu , Craig E Pennell , Paul M Ridker , Harold Snieder , Thorkild Ia Sørensen , Tim D Spector , David P Strachan , André G Uitterlinden , Nicholas J Wareham , Elisabeth Widen , Marek Zygmunt , Anna Murray , Douglas F Easton , Kari Stefansson , Joanne M Murabito , Ken K Ong |
2014-10-02 | - |
| 23279575 |
Cancer Sci. Yuriko Minegishi , Yoshio Shibagaki , Anna Mizutani , Koji Fujita , Tohru Tezuka , Masao Kinoshita , Masahiko Kuroda , Seisuke Hattori , Noriko Gotoh |
2013-03-01 | - |
| 20228838 |
Oncogene D Iejima , Y Minegishi , K Takenaka , A Siswanto , M Watanabe , L Huang , T Watanabe , F Tanaka , M Kuroda , N Gotoh |
2010-05-27 |
FRS3
|
| 19204726 |
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. Mol Psychiatry J Chapuis , D Hot , F Hansmannel , O Kerdraon , S Ferreira , C Hubans , C A Maurage , L Huot , F Bensemain , G Laumet , A M Ayral , N Fievet , J J Hauw , S T DeKosky , Y Lemoine , T Iwatsubo , F Wavrant-Devrièze , J F Dartigues , C Tzourio , L Buée , F Pasquier , C Berr , D Mann , C Lendon , A Alpérovitch , M I Kamboh , P Amouyel , J C Lambert |
2009-11-01 | - |
| 19322201 |
Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J Kotb Abdelmohsen , Subramanya Srikantan , Xiaoling Yang , Ashish Lal , Hyeon Ho Kim , Yuki Kuwano , Stefanie Galban , Kevin G Becker , Davida Kamara , Rafael de Cabo , Myriam Gorospe |
2009-05-06 | - |
| 18985028 |
Hepatitis C virus infection protein network. Mol. Syst. Biol. B de Chassey , V Navratil , L Tafforeau , M S Hiet , A Aublin-Gex , S Agaugué , G Meiffren , F Pradezynski , B F Faria , T Chantier , M Le Breton , J Pellet , N Davoust , P E Mangeot , A Chaboud , F Penin , Y Jacob , P O Vidalain , M Vidal , P André , C Rabourdin-Combe , V Lotteau |
2008-01-01 |
HCVgp1,
PSME3,
CALCOCO2,
BCKDK,
FBLN5,
FRS3,
PPP1R13L,
DDX3X,
FBLN2,
EFEMP1,
FTH1,
GBP2,
BIN1,
GOLGA2,
GPS2,
SETD2,
UBQLN1,
HIVEP2,
NR4A1,
HOXD8,
ITGAL,
JUN,
KPNA1,
NAP1L1,
NAP1L2,
TXNDC11,
RNF31,
MOB1A,
EIF4ENIF1,
PSMB9,
TRIM27,
VPS52,
SMURF2,
CEP85,
STAT3,
VIM,
VWF,
LTBP4,
SORBS2,
ACTN1,
SLIT2,
RASAL2,
MAGED1
|
| 16702953 |
Oncogene L Huang , M Watanabe , M Chikamori , Y Kido , T Yamamoto , M Shibuya , N Gotoh , N Tsuchida |
2006-10-19 |
FRS3
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员