| Type | Description |
|---|---|
| Definition | methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase |
| Date | Results | Publications |
|---|---|---|
| 2020-08-29 10:16:00 | Deletion of Mthfd1l causes decreased density in the cranial mesenchyme and this defect is improved with formate supplementation. This study reveals a mechanistic link between folate-dependent mitochondrially produced formate, head mesenchyme formation and neural tube defects. | 31518072 |
| 2019-03-09 12:51:00 | MTHFD1 synthetase-deficient mice are more sensitive to low folate intake than wild-type mice during pregnancy. | 29659962 |
| 2017-12-23 12:06:00 | Study evaluated cognitive function in Mthfd1(gt/+) male and female mice using a behavioral battery composed of eight different tests, found that these mice display impaired cue-conditioned learning, while other behaviors remain intact. | 28559181 |
| 2017-09-09 10:31:00 | Study observed decreased tumor growth in mice with reduced MTHFD1-synthetase activity, a model for the decreased metabolic activity of the human R653Q variant. These results propose that synthetase deficiency does not contribute to tumor initiation in the normal colon, but it limits tumor growth by reducing purine pools and altering expression of genes involved in cell proliferation and inflammation. | 27597531 |
| 2017-06-24 11:22:00 | Moderately higher folate intake and MTHFD1-synthetase deficiency in pregnant mice result in a lower methylation potential in maternal liver and embryos and a greater incidence of defects in embryos. | 27707701 |
| Type | IDs |
|---|---|
| Synonymous | Dcs, E430024A07Rik, Mthfd |
| Gene |
UniProtKB-ID:
C1TC_MOUSE,
Q3TW74_MOUSE,
Q8BXX7_MOUSE
UniprotKB:
Q922D8,
Q3TW74,
Q8BXX7
UniParc:
UPI00000E8844,
UPI00005AD34F,
UPI00000EA5FA
EMBL:
AF364581,
AF364582,
AF364591,
AF364583,
AF364584,
AK042958,
AF364580,
AF364579,
AK159812,
AK088700,
BC008523,
AF364588,
AF364589,
AF364590,
AF364585,
AF364587,
AF364586
Ensembl:
ENSMUSG00000021048
KO:
mmu:108156
|
| Nucleutide sequences |
EMBL-CDS:
AAH08523.1,
AAL99692.1,
AAL99693.1,
BAC40513.1,
BAE35392.1,
BAC31419.1
Ensembl_TRS:
ENSMUST00000021443
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000021443
RefSeq:
XP_030102369.1,
NP_620084.2
|
| Others |
UniRef100:
UniRef100_Q922D8,
UniRef100_Q3TW74
UniRef90:
UniRef90_Q922D8
UniRef50:
UniRef50_P11586
UniGene:
Mm.29584
CCDS:
CCDS25990.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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