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108153 Adamts7

108153

Adamts7

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7

protein-coding

Mus musculus

基因描述

Type Description
Definition a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7

研究结论

Date Results Publications
2019-11-30 12:28:00 Adamts7-/- Adamts12-/- mice, but not corresponding single-gene mutants, develop progressive heterotopic ossification (HO) in tendons with abnormal collagen fibrils, accompanied by reduced levels of the small leucine-rich proteoglycans which regulate collagen fibrillogenesis. These results suggest that Adamts7 and Adamts12 drive an innate pathway protective against hindlimb HO in mice. 29618652
2019-08-03 10:07:00 presents the expression levels of ADAMTS-7 and COMP in the decidual tissues of mice and humans suffering from SA. 30720083
2016-01-30 11:11:00 Therefore, these data provided the in vivo evidence, suggesting that ADAMTS-7 may play an important role in the pathogenesis of inflammatory arthritis. 25742929
2015-05-30 12:14:00 Mice lacking Adamts7, Ldlr, Apoe had less lesion formation in aortas and aortic roots vs controls and less neointimal formation after femoral wire injury. Adamts7 expression was induced by injury and hyperlipidemia. 25712206
2015-05-30 12:14:00 Adamts-7 deficiency substantially ameliorated neointima formation in mice at days 14 and 28 after injury. ADAMTS-7 inhibited both endothelial cell proliferation and migration. 25712208

名称对应

Type IDs
Synonymous ADAM-TS7, ADAMTS7B
Gene
UniProtKB-ID: ATS7_MOUSE, Q6PD18_MOUSE, F6UD05_MOUSE
UniprotKB: Q68SA9, Q6PD18, F6UD05
UniParc: UPI00015AA611, UPI00001D9480, UPI0001F78A42, UPI000035822B
EMBL: AY551090, AC151735, BC141173, BC058991, AC140392
Ensembl: ENSMUSG00000032363
KO: mmu:108153
Nucleutide sequences
EMBL-CDS: AAT36307.1, AAI41174.1, AAH58991.1
Ensembl_TRS: ENSMUST00000113059, ENSMUST00000113060, ENSMUST00000147250
Protein sequencees
Ensembl_PRO: ENSMUSP00000108683, ENSMUSP00000108682, ENSMUSP00000115972
RefSeq: NP_001003911.2, XP_030099860.1, XP_036010447.1, NP_001313280.1, XP_030099861.1, XP_006510822.1, NP_001298044.1, XP_006510823.1, NP_001313223.1, XP_006510825.1
Others
UniRef100: UniRef100_Q6PD18, UniRef100_Q68SA9, UniRef100_F6UD05
UniRef90: UniRef90_E9PX36, UniRef90_Q68SA9
UniRef50: UniRef50_Q9UKP4, UniRef50_Q1EHB3
UniGene: Mm.102141
CCDS: CCDS85708.1, CCDS40724.1

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