| Type | Description |
|---|---|
| Definition | protein kinase, AMP-activated, gamma 2 non-catalytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2018-10-06 10:16:00 | gamma2 AMPK activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower heart rate, including sarcolemmal hyperpolarization-activated current (I f) and ryanodine receptor-derived diastolic local subsarcolemmal Ca(2+) release. In contrast, loss of gamma2 AMPK induces a reciprocal phenotype of increased heart rate, and prevents the adaptive intrinsic bradycardia of endurance training. | 29097735 |
| 2017-12-16 12:25:00 | gamma2-specific AMPK activity was elevated in neonatal FNIP1-deficient myocardium, supporting a role for FNIP1 as a negative regulator of AMPK. | 27303042 |
| 2017-11-04 10:39:00 | Increased AMPK-gamma2 activation is required to protect against myocardial ischemia/reperfusion injury. | 28835357 |
| 2017-06-24 11:22:00 | mice with chronic AMPK activation, resulting from mutation of the AMPK gamma2 subunit, exhibit ghrelin signaling-dependent hyperphagia, obesity, and impaired pancreatic islet insulin secretion. Humans bearing the homologous mutation manifest a congruent phenotype. | 27133129 |
| 2017-06-03 12:08:00 | These results demonstrate that expression of AMPK subunit gamma-2(NI) and AMPK subunit gamma-2(RG) mutations at physiological levels can induce beneficial metabolic effects but that this is accompanied by Wolff-Parkinson-White Syndrome syndrome. | 27621313 |
| Type | IDs |
|---|---|
| Synonymous | 2410051C13Rik, AAKG, AAKG2, AI854673, H91620p, WPWS |
| Gene |
UniProtKB-ID:
AAKG2_MOUSE,
Q3TMN8_MOUSE,
Q8BIQ9_MOUSE
UniprotKB:
Q91WG5,
Q3TMN8,
Q8BIQ9
UniParc:
UPI000002304E,
UPI00000EB7BB,
UPI0000217891
EMBL:
AC125270,
AK032238,
AC116151,
AK165834,
AY348864,
BC015283
Ensembl:
ENSMUSG00000028944
KO:
mmu:108099
|
| Nucleutide sequences |
EMBL-CDS:
AAH15283.1,
AAQ55224.1,
BAE38403.1,
BAC27775.1
Ensembl_TRS:
ENSMUST00000114975,
ENSMUST00000030784,
ENSMUST00000076306
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000030784,
ENSMUSP00000110626,
ENSMUSP00000075651
RefSeq:
XP_036020617.1,
NP_001164026.1,
XP_011248042.1,
NP_663376.2,
NP_001297409.1,
XP_006535674.1,
XP_030109903.1,
XP_017176085.1,
XP_006535677.1,
XP_006535675.1,
NP_001164027.1,
XP_030109905.1,
XP_030109904.1,
XP_017176084.1
|
| Others |
UniRef100:
UniRef100_Q91WG5,
UniRef100_Q8BIQ9
UniRef90:
UniRef90_Q91WG5,
UniRef90_Q8BIQ9
UniRef50:
UniRef50_Q91WG5,
UniRef50_A0A1U8CPX9
UniGene:
Mm.33649
CCDS:
CCDS19130.1,
CCDS51437.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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