| Type | Description |
|---|---|
| Definition | centromere protein F |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:29:00 | Loss of CENPF leads to developmental failure in mouse embryos. | 31478449 |
| 2020-04-04 11:08:00 | Loss of CENP-F Function Induces Kidney Enlargement. | 30408335 |
| 2019-10-12 12:30:00 | Results found that loss of function mutation in CENPF results in dilated cardiomyopathy with significant disruption in the microtubule network of cardiac myocytes in mouse. | 29765066 |
| 2019-09-21 10:23:00 | Due to the multifunctionality of CENP-F, the cellular phenotypes observed upon its depletion are difficult to interpret and there is a need to genetically separate its different functions by preventing binding to selected partners. Here we engineer a CENP-F point-mutant that is deficient in Miro1/2 binding and thus is unable to localize to mitochondria, but retains other localizations. | 30856164 |
| 2017-09-02 10:20:00 | Our data show that mutation of the CENP-F gene leads to an unexpected hyperstabilization of the MT network, with a unique loss of dynamic instability. With disruption of MT dynamics, CENP-F-/- cells exhibit dramatic loss of directionally persistent migration, defects in focal adhesion disassembly and lamellipodial formation/retraction, change in cilia frequency, and loss of regulation of cell shape. | 27146114 |
| Type | IDs |
|---|---|
| Synonymous | 6530404A22Rik, AI325968, CENF, Lek1, PRO1779, mitosin |
| Gene |
UniProtKB-ID:
E9Q3P4_MOUSE
UniprotKB:
E9Q3P4
UniParc:
UPI00004762AA
EMBL:
AC140679
Ensembl:
ENSMUSG00000026605
KO:
mmu:108000
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000171929
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000129738
RefSeq:
NP_001074832.2,
XP_006497182.1
|
| Others |
UniRef100:
UniRef100_E9Q3P4
UniRef90:
UniRef90_Q155P7
UniRef50:
UniRef50_Q155P7
UniGene:
Mm.129746
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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