| Type | Description |
|---|---|
| Definition | centromere protein F |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:29:00 | Loss of CENPF leads to developmental failure in mouse embryos. | 31478449 |
| 2020-04-04 11:08:00 | Loss of CENP-F Function Induces Kidney Enlargement. | 30408335 |
| 2019-10-12 12:30:00 | Results found that loss of function mutation in CENPF results in dilated cardiomyopathy with significant disruption in the microtubule network of cardiac myocytes in mouse. | 29765066 |
| 2019-09-21 10:23:00 | Due to the multifunctionality of CENP-F, the cellular phenotypes observed upon its depletion are difficult to interpret and there is a need to genetically separate its different functions by preventing binding to selected partners. Here we engineer a CENP-F point-mutant that is deficient in Miro1/2 binding and thus is unable to localize to mitochondria, but retains other localizations. | 30856164 |
| 2017-09-02 10:20:00 | Our data show that mutation of the CENP-F gene leads to an unexpected hyperstabilization of the MT network, with a unique loss of dynamic instability. With disruption of MT dynamics, CENP-F-/- cells exhibit dramatic loss of directionally persistent migration, defects in focal adhesion disassembly and lamellipodial formation/retraction, change in cilia frequency, and loss of regulation of cell shape. | 27146114 |
| Type | IDs |
|---|---|
| Synonymous | 6530404A22Rik, AI325968, CENF, Lek1, PRO1779, mitosin |
| Gene |
UniProtKB-ID:
E9Q3P4_MOUSE
UniprotKB:
E9Q3P4
UniParc:
UPI00004762AA
EMBL:
AC140679
Ensembl:
ENSMUSG00000026605
KO:
mmu:108000
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000171929
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000129738
RefSeq:
NP_001074832.2,
XP_006497182.1
|
| Others |
UniRef100:
UniRef100_E9Q3P4
UniRef90:
UniRef90_Q155P7
UniRef50:
UniRef50_Q155P7
UniGene:
Mm.129746
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| 1 |
Vanderbilt University Medical Center |
7 |
| 2 |
Vanderbilt University |
6 |
| 3 |
Institute of Biochemistry and Cell Biology |
3 |
| 4 |
Columbia University Medical Center |
2 |
| 5 |
University of Manchester |
2 |
| 排名 | 研究人员 | 文献 |
|---|---|---|
| 1 |
David M Bader |
8 |
| 2 |
P Carninci |
7 |
| 3 |
Y Hayashizaki |
6 |
| 4 |
H Konno |
5 |
| 5 |
K Shibata |
5 |