| Type | Description |
|---|---|
| Definition | damage specific DNA binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2018-01-06 12:26:00 | DDB2 plays a critical role in suppressing development of colon cancer at early stage by regulating Wnt signaling. Mice genetically deficient in DDB2 exhibited increased susceptibility to colon tumor development in a manner associated with higher abundance of the Wnt receptor-expressing cells and greater activation of the downstream Wnt pathway. | 29021137 |
| 2017-08-19 12:04:00 | UVRAG is a regulator of CRL4(DDB2)-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition. | 27203177 |
| 2013-08-31 12:04:00 | Results indicate a transcriptional regulatory pathway of DDB2 that is directly linked to the mechanisms that suppress metastasis of colon cancer. | 23610444 |
| 2013-05-04 11:37:00 | Data indicate that poly(ADP-ribose) polymerase-1 with DNA-binding protein 2 (DDB2) to increase the efficiency of the lesion recognition step of global genomic subpathway of NER (GG-NER). | 23319653 |
| 2012-03-24 11:13:00 | the anti-proliferative and the pro-senescence pathways of DDB2 and p21 are critical protection mechanisms against skin malignancies. | 22167187 |
| Type | IDs |
|---|---|
| Synonymous | 2610043A19Rik |
| Gene |
UniProtKB-ID:
DDB2_MOUSE
UniprotKB:
Q99J79
UniParc:
UPI0000022B40
EMBL:
AY027937
Ensembl:
ENSMUSG00000002109
KO:
mmu:107986
|
| Nucleutide sequences |
EMBL-CDS:
AAK16810.1
Ensembl_TRS:
ENSMUST00000028696
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000028696
RefSeq:
NP_082395.2,
NP_001349634.1,
XP_036013206.1
|
| Others |
UniRef100:
UniRef100_Q99J79
UniRef90:
UniRef90_Q99J79
UniRef50:
UniRef50_Q92466
UniGene:
Mm.389334
CCDS:
CCDS16428.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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