| Type | Description |
|---|---|
| Definition | fibroblast growth factor receptor substrate 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-02-23 13:31:00 | FRS2 and FRS3, are together required for postnatal brain development. In the hippocampus, FRS2&3 promote dentate gyrus morphogenesis and dentate granule cell (DGC) maturation during developmental neurogenesis. Frs2,3-double mutants have reduced numbers of dendritic branches and spines in DGCs. Double-mutant mice exhibit fewer excitatory synaptic inputs onto DGCs. | 29155277 |
| 2014-06-21 13:01:00 | Analysis of a mutant Fgfr1 allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 maintenance can be | 24465223 |
| 2010-01-21 00:00:00 | ULK2, by interaction with FRS2/3 and inhibition of SynGAP, functions to negatively regulate tyrosyl phosphorylation of signaling proteins downstream of FGFR1. | 16887332 |
| 2010-01-21 00:00:00 | data indicate that the fibroblast growth factor receptor substrate 2 and fibroblast growth factor receptor substrate 3 adapters may have a role in thyroid carcinogenesis triggered by TRK oncogenes | 12586769 |
| 2010-01-21 00:00:00 | Some essential functions of Fgfr1 are mediated by Frs-independent signaling. | 16421190 |
| Type | IDs |
|---|---|
| Synonymous | 4930417B13Rik, AI449674, Frs2beta, Snt2 |
| Gene |
UniProtKB-ID:
FRS3_MOUSE
UniprotKB:
Q91WJ0
UniParc:
UPI00000293B5
EMBL:
AF456480,
BC014819
Ensembl:
ENSMUSG00000023266
KO:
mmu:107971
|
| Nucleutide sequences |
EMBL-CDS:
AAO15529.1,
AAH14819.1
Ensembl_TRS:
ENSMUST00000113296
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000108921
RefSeq:
XP_006523531.1,
XP_036016151.1,
NP_659188.1,
XP_006523532.1
|
| Others |
UniRef100:
UniRef100_Q91WJ0
UniRef90:
UniRef90_Q91WJ0
UniRef50:
UniRef50_Q91WJ0
UniGene:
Mm.392206
CCDS:
CCDS28854.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 29155277 |
Neuroscience Sayan Nandi , Karina Alviña , Pablo J Lituma , Pablo E Castillo , Jean M Hébert |
2018-01-15 | - |
| 28483978 |
FGF-Dependent, Context-Driven Role for FRS Adapters in the Early Telencephalon. J. Neurosci. Sayan Nandi , Grigoriy Gutin , Christopher A Blackwood , Nachiket G Kamatkar , Kyung W Lee , Gordon Fishell , Fen Wang , Mitchell Goldfarb , Jean M Hébert |
2017-06-07 | - |
| 26341559 |
Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes Dev J Richard Brewer , Andrei Molotkov , Pierre Mazot , Renée V Hoch , Philippe Soriano |
2015-09-01 | - |
| 26073538 |
Am. J. Reprod. Immunol. Jing Pan , Gil Mor , Weina Ju , Julia Zhong , Xiucui Luo , Paulomi Bole Aldo , Mei Zhong , Yanhong Yu , Edmund C Jenkins , William T Brown , Nanbert Zhong |
2015-09-01 |
Snx21,
Slco2b1,
Alg9,
Ttc7b,
Frs3,
Zdhhc15,
Plekha5,
Pkn2,
Ankrd39,
Atp9a,
Atrn,
Capn5,
Capn7,
Clcn2,
Col12a1,
Col18a1,
Col4a2,
Col4a3,
Col5a1,
Slc6a12,
Slc6a13,
Usp15,
Slc39a7,
Hk1,
Trpm8,
Trpm1,
Myo5a,
Myo6,
Abcb1a,
Ppp3cc,
Sox2,
Wdr37,
Alg1,
Tyw3,
Tmem51,
Rassf2,
Tgfa,
Btf3,
Xkr6,
Vmn2r30,
Sox21,
Rapgef3,
Abcf1,
Ttc7,
Zranb3,
Pkp4,
Adamtsl4,
Slc25a51,
Arhgef16,
Wnk1,
Gramd1b,
Slco2a1,
Plekha6,
Zdhhc13,
Rgma,
Snx17,
Rapgefl1,
Abcf2,
Adamts13,
Mga,
Adamts8,
Sycp2,
Parp4,
Tmem67,
Col27a1,
Arhgef15,
Atp8a2,
Gramd1a,
Zranb2,
Arhgap27,
Abhd2,
Abcb10,
Vmn2r53,
Ankrd37,
Alg5,
Trim13,
Psmd9,
Ccdc137,
Slc25a37,
Ccdc130,
Slc39a13,
Arl8a,
Tyw5,
Fam83g,
Wnk4,
Psmd1,
Wdr34,
Wdr43,
Usp13,
Fam83e,
Trim14,
Arl5b,
Abhd12,
Trappc9,
Wdr38,
Trappc6b,
Arhgap10,
Rassf10,
Tmem62
|
| 24465223 |
FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation. PLoS Genet. Kazuya Ono , Tomoko Kita , Shigeru Sato , Paul O'Neill , Siu-Shan Mak , Marie Paschaki , Masataka Ito , Noriko Gotoh , Kiyoshi Kawakami , Yoshiki Sasai , Raj K Ladher |
2014-01-01 |
Frs3,
Atoh1,
Bmp4,
Cdkn1b,
Emx2,
Fgf10,
Fgfr1,
Gt(ROSA)26Sor,
Hes5,
Hey2,
Foxg1,
Jag1,
Myo7a,
Ngfr,
Pax2,
Prox1,
Sox2,
Mapk1,
Mapk3,
Frs2
|
| 21677750 |
A conditional knockout resource for the genome-wide study of mouse gene function. Nature William C Skarnes , Barry Rosen , Anthony P West , Manousos Koutsourakis , Wendy Bushell , Vivek Iyer , Alejandro O Mujica , Mark Thomas , Jennifer Harrow , Tony Cox , David Jackson , Jessica Severin , Patrick Biggs , Jun Fu , Michael Nefedov , Pieter J de Jong , A Francis Stewart , Allan Bradley |
2011-06-15 | - |
| 21267068 |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. Graciana Diez-Roux , Sandro Banfi , Marc Sultan , Lars Geffers , Santosh Anand , David Rozado , Alon Magen , Elena Canidio , Massimiliano Pagani , Ivana Peluso , Nathalie Lin-Marq , Muriel Koch , Marchesa Bilio , Immacolata Cantiello , Roberta Verde , Cristian De Masi , Salvatore A Bianchi , Juliette Cicchini , Elodie Perroud , Shprese Mehmeti , Emilie Dagand , Sabine Schrinner , Asja Nürnberger , Katja Schmidt , Katja Metz , Christina Zwingmann , Norbert Brieske , Cindy Springer , Ana Martinez Hernandez , Sarah Herzog , Frauke Grabbe , Cornelia Sieverding , Barbara Fischer , Kathrin Schrader , Maren Brockmeyer , Sarah Dettmer , Christin Helbig , Violaine Alunni , Marie-Annick Battaini , Carole Mura , Charlotte N Henrichsen , Raquel Garcia-Lopez , Diego Echevarria , Eduardo Puelles , Elena Garcia-Calero , Stefan Kruse , Markus Uhr , Christine Kauck , Guangjie Feng , Nestor Milyaev , Chuang Kee Ong , Lalit Kumar , MeiSze Lam , Colin A Semple , Attila Gyenesei , Stefan Mundlos , Uwe Radelof , Hans Lehrach , Paolo Sarmientos , Alexandre Reymond , Duncan R Davidson , Pascal Dollé , Stylianos E Antonarakis , Marie-Laure Yaspo , Salvador Martinez , Richard A Baldock , Gregor Eichele , Andrea Ballabio |
2011-01-18 | - |
| 19943849 |
J. Neurochem. Todd Hryciw , James I S MacDonald , Renée Phillips , Claudia Seah , Stephen Pasternak , Susan O Meakin |
2010-02-01 |
Frs3,
Calr,
Canx,
Eomes,
Flot1,
Gfap,
Mki67,
Nes,
Pdpk1,
Rab5b,
Shc3,
Eea1,
Tubb3,
Rbfox3,
Stx6
|
| 19187780 |
FEBS Lett. Yuriko Minegishi , Hiroko Iwanari , Yasuhiro Mochizuki , Takako Horii , Tomoko Hoshino , Tatsuhiko Kodama , Takao Hamakubo , Noriko Gotoh |
2009-02-18 |
Frs3
|
| 18799693 |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. Gwenn M Hansen , Diane C Markesich , Michael B Burnett , Qichao Zhu , Karen M Dionne , Lizabeth J Richter , Richard H Finnell , Arthur T Sands , Brian P Zambrowicz , Alejandro Abuin |
2008-10-01 |
Gm11335,
Gm17762,
A930017K11Rik,
BC028777,
Gm13999,
Gm11696,
Gm12359,
Gm10589,
D030047H15Rik,
Gm10856,
Gm10685,
Gm10062,
Gm10433,
Gm10648,
Gm10840,
Gm15441,
Gm10684,
Gm9900,
Gm10822,
Gm10687,
Gm11744,
Gm10747,
Arih2os,
B230344G16Rik,
Fmr1os,
Tmem51os1,
Gm14488,
Gm13033,
Gm10789,
Gm10615,
Gm1976,
Gm9967,
Gm9917,
Gm1974,
Gm11496,
Gm13580,
Gm2085,
Gm2183,
Gm2245,
Tbx3os1,
Gm12980,
Gm2329,
Lncenc1,
Gm2381,
Snhg12,
Gm2479,
Gm12942,
Gm2529,
Gm2533,
Rpl30-ps7,
Rsf1os2,
Gm2695,
2810416G20Rik,
Rpl30-ps6,
Gm2773,
Gm2788,
Dynlt1f,
Gm9793,
Gm2885,
Gm2920,
Gm15506,
Gm11627,
Gm10518,
Gm13496,
Gm3134,
Gm12827,
Gm3143,
Gm10144,
Ahnak2,
Gm3196,
Gm13242,
Gm3325,
Gm13247,
Gm10863,
Gm13157,
4930522L14Rik,
Gm3552,
Gm15226,
Gm3604,
Gm3643,
BC005561,
Gm3716,
2810410L24Rik,
Gm10282,
Gm3839,
Nhsl2,
4732419C18Rik,
Gm3906,
Gm3973,
Gm4013,
Apol7d,
Gm12057,
Gm10489,
Rex2,
1110002L01Rik,
Gm4189,
Gm4204,
4632428C04Rik,
9130023H24Rik
|
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|---|---|---|
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