| Type | Description |
|---|---|
| Definition | solute carrier family 12, member 6 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:54:00 | Osmotic Response of Dorsal Root Ganglion Neurons Expressing Wild-Type and Mutant KCC3 Transporters. | 32506846 |
| 2020-07-25 12:01:00 | the effect of genetic inactivation of K-Cl cotransporters KCC1 and KCC3 in a mouse model of beta-thalassemia intermedia; conclude that genetic inactivation of K-Cl cotransport can reverse red cell dehydration and partially attenuate the hematologic phenotype in a mouse model of beta-thalassemia. | 31835175 |
| 2020-02-08 12:50:00 | effect of genetic inactivation of KCC3 and KCC1 in the SAD mouse model of sickle red cell dehydration, finding decreased red cell density and improved hematological indices. | 31352162 |
| 2018-05-19 11:36:00 | Results reveal the role of electrical activity in the process of neuromuscular junction (NMJ) denervation and subsequent neurodegeneration in Andermann syndrome. Study found that loss of KCC3 function is associated with an abnormal intrinsic neuronal electrical activity. Notably, we show that pharmacologically decreasing the firing frequency of Slc12a6-/- motoneurons partially rescues innervation at the NMJ. | 28647557 |
| 2017-12-23 11:14:00 | electrophysiological studies using the threshold tracking technique indicated a reduced stimulus-response curve slope with an elevated rheobase, a decreased strength-duration time constant, diminished persistent Na(+) currents, and an outward deviation of threshold electrotonus in KCC3(-/-) nerves compared to wild-type nerves | 27568057 |
| Type | IDs |
|---|---|
| Synonymous | 9530023I19Rik, KCC3, gaxp |
| Gene |
UniProtKB-ID:
S12A6_MOUSE,
Q3V0N8_MOUSE
UniprotKB:
Q924N4,
Q3V0N8
UniParc:
UPI0000022AEB,
UPI00005AB91A,
UPI0000194BC0
EMBL:
AF211855,
CH466519,
AK133006,
AF211854,
AL683897,
AL713853
Ensembl:
ENSMUSG00000027130
KO:
mmu:107723
|
| Nucleutide sequences |
EMBL-CDS:
AAK81895.1,
EDL27838.1,
AAK81896.1,
BAE21466.1
Ensembl_TRS:
ENSMUST00000028549,
ENSMUST00000053666,
ENSMUST00000110991
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000028549,
ENSMUSP00000051490,
ENSMUSP00000106619
RefSeq:
XP_006498609.1,
NP_598409.2,
NP_001349629.1,
NP_598410.2
|
| Others |
UniRef100:
UniRef100_Q3V0N8,
UniRef100_Q924N4
UniRef90:
UniRef90_Q9UHW9
UniRef50:
UniRef50_Q9UHW9
UniGene:
Mm.491155
CCDS:
CCDS16551.1,
CCDS16552.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员