| Type | Description |
|---|---|
| Definition | deiodinase, iodothyronine type III |
| Date | Results | Publications |
|---|---|---|
| 2020-08-12 15:05:00 | The extent of the molecular and behavioral phenotypes of adult-onset DIO3 deficiency suggests that a substantial proportion of the neurological abnormalities caused by constitutive DIO3 deficiency has a developmental origin. However, DIO3 in the adult brain also influences behavior and sensitivity to thyroid hormone action in a sexually dimorphic fashion. | 31561084 |
| 2020-05-02 10:06:00 | Deletion of miRNAs encoded by the Dlk1-Dio3 locus reduced gluconeogenesis, glucose intolerance, and fasting blood glucose levels. Thus, miRNAs contribute to the metabolic effects observed upon loss of TSC1 and hyperactivation of mTORC1 in the liver. | 31919282 |
| 2019-12-28 12:37:00 | Spermatogonial DIO3 protects testicular cells from untimely thyroid hormone signaling. | 31621880 |
| 2019-03-16 10:16:00 | Paternal inheritance of IG-DMR-Rep deletion allele resulted in loss of methylation imprints at IG-DMR through embryonic development and maternalization of the paternal Dlk1-Dio3 domain, indicating that IG-DMR-Rep is essential for paternal-derived imprinting status of the domain through maintenance of DNA methylation at paternal IG-DMR. | 29931170 |
| 2019-03-02 10:18:00 | Mice experiencing a 3 hours of status epilepticus exhibit a rapid increase in expression of Dio2 and a decrease in the expression of Dio3 gene in hippocampus, amygdala and prefrontal cortex. | 29905787 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
IOD3_MOUSE
UniprotKB:
Q91ZI8
UniParc:
UPI0001B1A4BB
EMBL:
AK140797,
AL591207,
BC106848,
BC106847,
AK146060,
AF426023
Ensembl:
ENSMUSG00000075707
KO:
mmu:107585
|
| Nucleutide sequences |
EMBL-CDS:
AAI06848.1,
BAE26869.1,
AAL23960.1,
AAI06849.1,
BAE24483.1
Ensembl_TRS:
ENSMUST00000173014
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000133920
RefSeq:
NP_742117.2
|
| Others |
UniRef100:
UniRef100_Q91ZI8
UniRef90:
UniRef90_Q91ZI8
UniRef50:
UniRef50_Q91ZI8
UniGene:
Mm.154427
CCDS:
CCDS26171.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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