| Type | Description |
|---|---|
| Definition | TRAF3 interacting protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:15:00 | Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration. | 31239234 |
| 2020-07-11 10:07:00 | We describe an adolescent boy with recurrent oral candidiasis and bronchiectasis due to a novel mutation in TRAF3IP2 gene, not reported to date. This is also the only second report of CMC due to ACT1 deficiency. | 31292894 |
| 2020-06-20 12:38:00 | increased MMP-13 and decreased RECK contribute to IL-17A-induced TRAF3IP2-dependent smooth muscle cell migration and proliferation. | 31074012 |
| 2020-05-09 11:12:00 | Study results implicate neutrophil extracellular traps (NETs) and the T allele of rs33980500 (T/C), a psoriasis risk-associated variant in the TRAF3IP2 gene encoding the D10N variant of Act1, in human Th17 induction from peripheral blood mononuclear cells and verified that the effect of Act1 D10N was greater in the presence of NETs. | 30528823 |
| 2019-08-17 11:04:00 | We also identify a novel LRI site located within the TRAF3IP2-AS1 promoter, 200 kb distant from the TRAF3IP2 promoter, showing genetic association with psoriasis both in our discovery cohort, as well as in the large WTCCC replication cohort. | 30076642 |
| Type | IDs |
|---|---|
| Synonymous | ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13 |
| Gene |
UniProtKB-ID:
CIKS_HUMAN
UniprotKB:
O43734
UniParc:
UPI00001A3A90,
UPI00001A3A8F,
UPI000013DDEF,
UPI000013C575,
UPI000016A2D3
EMBL:
CH471051,
AL008730,
AF136405,
Z97989,
AF274303,
AF136406,
AF136407,
AL050289,
AF272151,
AK314415,
AK025351,
AK026602,
BI856094,
BC002823
Ensembl:
ENSG00000056972
KO:
hsa:10758
|
| Nucleutide sequences |
EMBL-CDS:
AAH02823.1,
AAF67447.1,
AAG15407.1,
BAB15117.1,
AAG15367.1,
AAF67446.1,
BAG37036.1,
AAF67445.1,
EAW48285.1,
BAB15507.1,
EAW48287.1,
CAB43390.1
Ensembl_TRS:
ENST00000368730,
ENST00000392556,
ENST00000368734,
ENST00000340026,
ENST00000359831,
ENST00000368761,
ENST00000368735
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000345984,
ENSP00000498345,
ENSP00000352889,
ENSP00000376339,
ENSP00000498323,
ENSP00000357750,
ENSP00000357724
RefSeq:
NP_001157755.1,
NP_001157753.1,
NP_679211.2,
NP_671733.2
|
| Others |
UniRef100:
UniRef100_O43734
UniRef90:
UniRef90_O43734
UniRef50:
UniRef50_O43734
UniGene:
Hs.561514,
Hs.740602
CCDS:
CCDS5093.1,
CCDS55050.1,
CCDS55049.1,
CCDS5092.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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