| Type | Description |
|---|---|
| Definition | WW domain containing E3 ubiquitin protein ligase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-28 13:14:00 | The ubiquitin ligase WWP1 contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart. | 32822210 |
| 2020-05-16 10:56:00 | Abundance of KLF15 as well as the expression of genes related to muscle atrophy are increased in skeletal muscle of diabetic model mice, and mice with muscle-specific KLF15 deficiency are protected from the diabetes-induced decline of skeletal muscle mass. Hyperglycemia upregulates the KLF15 protein in skeletal muscle of diabetic animals, which is achieved via downregulation of the E3 ubiquitin ligase WWP1. | 30830866 |
| 2019-08-24 12:19:00 | Study delineatea a novel regulatory pathway that involves Sox9-[Wwp1/Wwp2/miR-140]-Fyn required for axon specification, acquisition of pyramidal morphology, and proper laminar distribution of cortical neurons. | 30392800 |
| 2019-06-08 10:54:00 | WWP1 was upregulated in obese white adipose tissue in a p53-dependent manner. To investigate the functions of WWP1 in adipocytes, a proteome analysis of WWP1 overexpression (OE) and knockdown (KD) 3T3-L1 cells was performed. This analysis showed a positive correlation between WWP1 expression and the abundance of several antioxidative proteins. | 30471861 |
| 2017-06-24 12:36:00 | Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin. This suggests that the E3 ligase WWP1 is involved in the pathogenesis of Huntington's disease; therefore, it may be a novel target for therapeutic intervention. | 27107943 |
| Type | IDs |
|---|---|
| Synonymous | 8030445B08Rik, AIP5, SDRP1, Tiul1 |
| Gene |
UniProtKB-ID:
WWP1_MOUSE,
Q3UV52_MOUSE,
Q05CE4_MOUSE
UniprotKB:
Q8BZZ3,
Q3UV52,
Q05CE4
UniParc:
UPI00001AAC7F,
UPI00005ABD9B,
UPI000059DEFE
EMBL:
AK033138,
BC026829,
AK082346,
BC021470,
BC051405,
AK137588
Ensembl:
ENSMUSG00000041058
KO:
mmu:107568
|
| Nucleutide sequences |
EMBL-CDS:
AAH21470.1,
AAH51405.1,
BAC28168.1,
BAC38473.1,
BAE23421.1,
AAH26829.1
Ensembl_TRS:
ENSMUST00000108246,
ENSMUST00000035982
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000041627,
ENSMUSP00000103881
RefSeq:
NP_001342151.1,
NP_001263221.1,
XP_006537609.1,
NP_796301.2
|
| Others |
UniRef100:
UniRef100_Q05CE4,
UniRef100_Q8BZZ3,
UniRef100_Q3UV52
UniRef90:
UniRef90_Q8BZZ3
UniRef50:
UniRef50_Q8BZZ3
UniGene:
Mm.78312,
Mm.474845
CCDS:
CCDS38697.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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