| Type | Description |
|---|---|
| Definition | cell adhesion molecule L1 like |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:30:00 | Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma. | 33326488 |
| 2019-11-30 10:13:00 | CHL1 expression levels were significantly higher in ovarian endometriosis tissue than in eutopic endometrium. | 30943448 |
| 2019-08-31 11:12:00 | The prognostic significance of CHL1 makes it a potential prognostic and therapeutic target and underlines its role as a tumour suppressor. Further validation studies and functional analyses are needed to investigate its potential role in tumourigenesis and dissemination. | 31372722 |
| 2019-05-18 11:45:00 | Results identified a new tumor suppressor, CHL1, located at 3p26 which was frequently deleted in esophageal squamous cells carcinoma (ESCC). Reduced expression of CHL1 correlated with poor differentiation, increased invasion, lymph-node metastasis, advanced tumor stage, and decreased overall survival. Further data support CHL1 as an important tumor suppressor with both anti-proliferation and anti-metastasis abilities. | 30622339 |
| 2019-01-19 11:48:00 | Expression level of miR-21-5p increased in both colon adenocarcinoma (COAD) tissues and cells. The result of in vivo experiments showed that down-regulation of miR-21-5p decreased the volume and weight of tumor, while knockdown of CHLI stimulated tumor growth. The overexpression of miR-21-5p can promote propagation and invasiveness of (COAD) cells through inhibiting the expression of CHL1. | 30134821 |
| Type | IDs |
|---|---|
| Synonymous | CALL, L1CAM2 |
| Gene |
UniProtKB-ID:
NCHL1_HUMAN,
A0A087X0M8_HUMAN
UniprotKB:
O00533,
A0A087X0M8
UniParc:
UPI000013CF0F,
UPI000020A9FC,
UPI0000E08093
EMBL:
AC066595,
BC143496,
AC026187,
AC011609,
AF002246,
BC104918,
AB209329
Ensembl:
ENSG00000134121
KO:
hsa:10752
|
| Nucleutide sequences |
EMBL-CDS:
AAI04919.1,
AAI43497.1,
BAD92566.1,
AAB60937.1
Ensembl_TRS:
ENST00000397491,
ENST00000256509,
ENST00000620033
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000256509,
ENSP00000380628,
ENSP00000483512
RefSeq:
XP_016861056.1,
XP_006713002.1,
XP_011531596.1,
NP_001240316.1,
XP_011531594.1,
XP_016861055.1,
NP_001240317.1,
XP_006713001.1,
XP_006713003.1,
XP_016861060.1,
XP_011531597.1,
XP_011531598.1,
XP_016861061.1,
XP_016861057.1,
NP_006605.2,
XP_016861059.1,
XP_016861062.1,
XP_016861058.1
|
| Others |
UniRef100:
UniRef100_O00533,
UniRef100_A0A087X0M8
UniRef90:
UniRef90_O00533,
UniRef90_O00533-2
UniRef50:
UniRef50_P70232
UniGene:
Hs.148909,
Hs.731409
CCDS:
CCDS58812.1,
CCDS2556.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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