| Type | Description |
|---|---|
| Definition | glucocorticoid modulatory element binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-07 11:43:00 | Our findings show the de-ubiquitinase USP40 regulates the ubiquitination and degradation of CFLARL; and GMEB1 acts as a bridge protein for USP40 and CFLARL. Mechanistically, we found GMEB1 inhibits the activation of CASP8 by modulating ubiquitination and degradation of CFLARL | 31046799 |
| 2010-01-21 00:00:00 | GMEB1 is an endogenous regulator that selectively binds to initiator procaspases and inhibits caspase-induced apoptosis | 16497673 |
| 2010-01-21 00:00:00 | GMEB1 effectively attenuated caspase activation and apoptosis caused by these stresses in human neuroblastoma SK-N-MC cells, indicating that it functions as a potent inhibitor of caspase activation and apoptosis in response to oxidative stress. | 18455874 |
| 2010-01-21 00:00:00 | 1.55 A resolution crystal structure of a central portion of GMEB1, encompassing its SAND domain | 12702733 |
| 2010-01-21 00:00:00 | GMEB1 is capable of binding to the prodomain of caspase-2; findings indicated that GMEB1 might be an endogenous inhibitory protein that selectively interacts with prodomain of caspase-2 to disrupt the autoactivation | 15555560 |
| Type | IDs |
|---|---|
| Synonymous | P96PIF, PIF96 |
| Gene |
UniProtKB-ID:
GMEB1_HUMAN,
B2RCN8_HUMAN,
B1AT47_HUMAN
UniprotKB:
Q9Y692,
B2RCN8,
B1AT47
UniParc:
UPI000002AAA5,
UPI00017507E4,
UPI000012B8AB
EMBL:
AF203694,
AK315436,
AL645729,
AK315195,
AF173868,
BC001473,
CH471059,
AK000892,
AF099013
Ensembl:
ENSG00000162419
KO:
hsa:10691
|
| Nucleutide sequences |
EMBL-CDS:
BAA91410.1,
AAD39355.1,
AAG01189.1,
AAH01473.1,
EAX07677.1,
AAD51352.1,
BAG37635.1,
EAX07679.1,
BAG37824.1,
EAX07676.1,
EAX07678.1
Gene_ORFName:
hCG_1787575
Ensembl_TRS:
ENST00000294409,
ENST00000361872,
ENST00000373816
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000362922,
ENSP00000355186,
ENSP00000294409
RefSeq:
NP_001306603.1,
XP_011538824.1,
XP_011538823.1,
NP_006573.2,
XP_016855576.1,
XP_011538820.1,
XP_011538821.1,
NP_077808.1
|
| Others |
UniRef100:
UniRef100_B2RCN8,
UniRef100_Q9Y692,
UniRef100_B1AT47
UniRef90:
UniRef90_Q9Y692
UniRef50:
UniRef50_Q9Y692
UniGene:
Hs.632373
CCDS:
CCDS328.1,
CCDS327.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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