| Type | Description |
|---|---|
| Definition | delta like canonical Notch ligand 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-05 11:03:00 | DLL3 is expressed at high frequency (74%) in stage IV pulmonary large cell neuroendocrine carcinoma and is a potential therapy target. | 31678831 |
| 2020-07-18 11:01:00 | DLL3 expression is reliably quantifiable by pathologists and is highly expressed in the majority of SCLC and a subset of carcinoid tumors, making it an attractive target for anti-DLL3 treatment. | 31447005 |
| 2020-06-20 11:52:00 | LIN28B and miR-518d-5p could regulate DLL3-mediated cell proliferation and migration. | 31079917 |
| 2020-06-20 11:18:00 | Delta-like ligand 3 (DLL3) is an inhibitory Notch ligand that is highly expressed in Small cell lung cancer (SCLC) and other neuroendocrine tumors but minimally expressed in normal tissues. It is therefore being explored as a potential therapeutic target in SCLC. [review] | 31215500 |
| 2020-04-25 12:33:00 | DLL3 is selectively and homogeneously expressed in IDH-mutant gliomas and can be targeted with Rova-T in patient-derived IDH-mutant glioma tumorspheres. | 30397180 |
| Type | IDs |
|---|---|
| Synonymous | SCDO1 |
| Gene |
UniProtKB-ID:
DLL3_HUMAN
UniprotKB:
Q9NYJ7
UniParc:
UPI0000051041,
UPI000020233D
EMBL:
AF241368,
AF241373,
AF241370,
AF241367,
BC000218,
AF241369,
AF241372,
AC011500,
AF241371,
AK075302
Ensembl:
ENSG00000090932
KO:
hsa:10683
|
| Nucleutide sequences |
EMBL-CDS:
AAH00218.1,
BAC11535.1,
AAF62542.1
Ensembl_TRS:
ENST00000205143,
ENST00000356433
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000348810,
ENSP00000205143
RefSeq:
NP_982353.1,
NP_058637.1
|
| Others |
UniRef100:
UniRef100_Q9NYJ7
UniRef90:
UniRef90_Q9NYJ7
UniRef50:
UniRef50_Q9NYJ7
UniGene:
Hs.127792
CCDS:
CCDS12538.1,
CCDS12537.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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