| Type | Description |
|---|---|
| Definition | carboxylesterase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 11:54:00 | In the combined cohort, CES1 rs9921399T>C was associated with prolonged overall survival (OS) (hazard ratio [HR] = 0.40) whereas ABCC1 rs17501011G>A (HR = 2.08) and UGT1 rs1113193G>A (HR = 2.12) were associated with shorter OS (p | 31698983 |
| 2020-05-23 10:58:00 | Studied role of CYP450 Enzymes, carboxylesterase 1(CES1), paraoxonase 1(PON1), ATP binding cassette subfamily B member 1(ABCB1), and purinergic receptor P2Y12 (P2RY12) genetic polymorphisms in the response to clopidogrel treatment who had undergone neurointervention. | 31128980 |
| 2020-04-11 12:41:00 | Provides important insights into the metabolism of hCES1 substrates and drug designing. | 31717501 |
| 2020-01-25 13:12:00 | A potential for clinically significant inhibition of CES1 by THC and CBD. | 30833288 |
| 2020-01-11 12:40:00 | The study has shown the CES1 gene SNP rs2244613 frequency heterogeneity in different ethnic groups in Russia. Based on these findings and the RE-LY conclusions about rs2244613 carriage association with dabigatran concentration and the risk of bleeding we can suppose that patients taking dabigatran in ethnic groups living in Russia have a lower risk of bleeding. | 30850966 |
| Type | IDs |
|---|---|
| Synonymous | ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 |
| Gene |
UniProtKB-ID:
EST1_HUMAN
UniprotKB:
P23141
UniParc:
UPI000004A443,
UPI000054B390,
UPI000054B38F
EMBL:
M55509,
BC012418,
M65261,
L07765,
AB119995,
AK290623,
X52973,
S73751,
AY268104,
AB119997,
AB119996,
L07764,
AB025026,
M73499,
D21088,
BC110338,
AF177775,
AB119998,
AK292209,
AC147362
Ensembl:
ENSG00000198848,
ENSG00000262243
KO:
hsa:1066
|
| Nucleutide sequences |
EMBL-CDS:
BAC87748.1,
AAH12418.1,
AAA16036.1,
BAC87749.1,
AAD53175.1,
BAA84995.1,
AAA35711.1,
AAP20868.1,
BAA04650.1,
BAC87751.1,
BAC87750.1,
AAA35650.1,
AAC60631.2,
BAF83312.1,
AAA83932.1,
AAA35649.1,
AAI10339.1,
CAA37147.1,
BAF84898.1
Ensembl_TRS:
ENST00000361503,
ENST00000360526,
ENST00000422046,
ENST00000571922,
ENST00000574513,
ENST00000576783
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000460045,
ENSP00000355193,
ENSP00000353720,
ENSP00000390492,
ENSP00000461208,
ENSP00000458586
RefSeq:
XP_005255831.1,
NP_001020366.1,
NP_001257.4,
NP_001020365.1
|
| Others |
UniRef100:
UniRef100_P23141
UniRef90:
UniRef90_P23141
UniRef50:
UniRef50_P23141
UniGene:
Hs.558865
CCDS:
CCDS45488.1,
CCDS32450.1,
CCDS45489.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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