| Type | Description |
|---|---|
| Definition | serine peptidase inhibitor, Kunitz type 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 12:59:00 | Loss of SPINT2 expression frequently occurs in glioma, leading to increased growth and invasion via MMP2. | 31701492 |
| 2020-10-03 12:53:00 | SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses. | 32056846 |
| 2020-06-20 12:40:00 | down-regulation in SPINT2/HAI-2 gene expression, due to methylation in myelodysplastic syndromes (MDS)-bone marrow mesenchymal stromal cell (BMMSC) and de novo acute myeloid leukaemia -BMMSC, provides novel insights into the pathogenic role of the leukemic bone marrow microenvironment. | 30484958 |
| 2020-03-14 12:27:00 | our results suggest that the SCSD-associated mutations in HAI-2 may cause the disease due to reduced ability to inhibit prostasin or a prostasin-like protease. | 30445423 |
| 2019-12-14 12:29:00 | HAI-2 functions as a novel inhibitor of plasmin to suppress lung adenocarcinoma cell motility, epithelial-mesenchymal transition and metastasis. | 30765871 |
| Type | IDs |
|---|---|
| Synonymous | DIAR3, HAI-2, HAI2, Kop, PB |
| Gene |
UniProtKB-ID:
SPIT2_HUMAN,
A0A140VJV6_HUMAN
UniprotKB:
O43291,
A0A140VJV6
UniParc:
UPI00001B215D,
UPI0000135E8E
EMBL:
BT020115,
AF027205,
BC012868,
AK297154,
AB006534,
AK291532,
BC007705,
U78095,
BC011951,
CH471126,
BT020117,
BC011955,
BT020116,
AC011479,
HM005496,
BC001668
Ensembl:
ENSG00000167642
KO:
hsa:10653
|
| Nucleutide sequences |
EMBL-CDS:
AAV38920.1,
AAH11955.1,
AAC02781.1,
EAW56766.1,
AAH01668.1,
BAG59653.1,
EAW56767.1,
AAH11951.1,
AAV38918.1,
BAF84221.1,
AAH07705.1,
AAV38919.1,
AAB84031.1,
BAA25024.1,
AAH12868.1,
AEE61093.1
Ensembl_TRS:
ENST00000454580,
ENST00000301244
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000389788,
ENSP00000301244
RefSeq:
NP_066925.1,
NP_001159575.1
|
| Others |
UniRef100:
UniRef100_A0A140VJV6,
UniRef100_O43291
UniRef90:
UniRef90_A0A2I3HHB4,
UniRef90_O43291
UniRef50:
UniRef50_Q9WU03-2,
UniRef50_O43291
UniGene:
Hs.31439
CCDS:
CCDS54261.1,
CCDS12510.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员