| Type | Description |
|---|---|
| Definition | NPR2 like, GATOR1 complex subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:26:00 | NPRL2 promotes docetaxel chemoresistance in castration resistant prostate cancer cells by regulating autophagy through the mTOR pathway. | 32234375 |
| 2019-07-06 12:22:00 | these results demonstrate a new role for the NPRL2, distinct from its function in mTORC1 regulation. | 29127423 |
| 2019-05-04 10:14:00 | Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases. | 30651352 |
| 2019-04-20 10:10:00 | overall, 63 distinct variants were identified: 53 in DEPDC5, three in NPRL2 and seven in NPRL3 . Among these, 46 were novel (including 39 single nucleotide variants and seven CNVs) and 16 were newly defined as recurrent variants; 34 were loss-of-function (LoF) variants (nonsense, splice-site, frameshift indels and CNVs). | 30093711 |
| 2019-04-13 10:49:00 | The expression level of NPRL2 was significantly up-regulated in prostate cancer and its high expression was correlated with poor prognosis. | 29458069 |
| Type | IDs |
|---|---|
| Synonymous | FFEVF2, NPR2, NPR2L, TUSC4 |
| Gene |
UniProtKB-ID:
NPRL2_HUMAN
UniprotKB:
Q8WTW4
UniParc:
UPI000006EA5C,
UPI0000072BFE
EMBL:
AC002481,
AK292196,
BC021984,
AF040707,
CR542035,
AF040708,
CH471055,
BC056861
Ensembl:
ENSG00000114388
KO:
hsa:10641
|
| Nucleutide sequences |
EMBL-CDS:
AAH21984.1,
AAC62535.1,
AAC62536.1,
AAB67310.1,
AAH56861.1,
CAG46832.1,
BAF84885.1,
EAW65107.1,
EAW65106.1
Ensembl_TRS:
ENST00000232501
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000232501
RefSeq:
XP_016861044.1,
XP_016861045.1,
XP_005264865.1,
XP_011531590.1,
NP_006536.3
|
| Others |
UniRef100:
UniRef100_Q8WTW4
UniRef90:
UniRef90_Q8WTW4
UniRef50:
UniRef50_Q8WTW4
UniGene:
Hs.437083
CCDS:
CCDS2826.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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