| Type | Description |
|---|---|
| Definition | F-box protein 4 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-14 12:13:00 | These findings suggest a role of Hsp20 in mediating adipocyte function by linking beta-adrenergic signaling to PPARgamma activity. | 29925002 |
| 2016-03-05 11:26:00 | Collectively, our data support a role for FBXO4 as a suppressor of esophageal tumorigenesis | 25801820 |
| 2013-12-28 11:40:00 | This study demonstrates that Fbxo4 deficiency induces Braf-driven melanoma and that this phenotype depends on cyclin D1 accumulation in mice, underscoring the importance of this ubiquitin ligase in tumor suppression. | 24019069 |
| 2011-12-24 10:04:00 | Fbx4 expression is essential for cell homeostasis in somatic cells. Fbx4 ablation predisposes mice to multiple tumor phenotypes, with concomitant cyclin D1 deregulation and nuclear accumulation | 21911473 |
| 2010-01-21 00:00:00 | SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1. | 17081987 |
| Type | IDs |
|---|---|
| Synonymous | 1700096C12Rik, AI851261, AW494535, Fbx4 |
| Gene |
UniProtKB-ID:
FBX4_MOUSE
UniprotKB:
Q8CHQ0
UniParc:
UPI00001C5714
EMBL:
AJ300659,
AC137902,
BC040086
Ensembl:
ENSMUSG00000022184
KO:
mmu:106052
|
| Nucleutide sequences |
EMBL-CDS:
CAC36404.1,
AAH40086.1
Ensembl_TRS:
ENSMUST00000022791
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000022791
RefSeq:
NP_598860.2
|
| Others |
UniRef100:
UniRef100_Q8CHQ0
UniRef90:
UniRef90_Q8CHQ0
UniRef50:
UniRef50_Q9UKT5
UniGene:
Mm.234191
CCDS:
CCDS27359.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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