| Type | Description |
|---|---|
| Definition | centromere protein C |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:17:00 | A genetic memory initiates the epigenetic loop necessary to preserve centromere position. | 32945564 |
| 2020-06-06 12:24:00 | CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization | 31676716 |
| 2020-05-16 11:18:00 | two key conformational changes within the CENP-A nucleosome upon CENP-C binding, are reported. | 31475439 |
| 2019-02-09 11:49:00 | CENP-N stabilizes CENP-A nucleosomes alone and additively with CENP-C in vitro. However, removal of CENP-C and CENP-N from cells, or mutating CENP-A so that it no longer interacts with CENP-C or CENP-N, had no effect on centromeric CENP-A stability in vivo. Thus, the stability of CENP-A nucleosomes in chromatin does not arise solely from its interactions with CENP-C or CENP-N. | 29343552 |
| 2018-08-25 11:48:00 | Collectively, these studies clarify how CENP-N and CENP-C decode and stabilize the non-canonical CENP-A nucleosome to enforce epigenetic centromere specification and kinetochore assembly. | 29280735 |
| Type | IDs |
|---|---|
| Synonymous | CENP-C, CENPC1, MIF2, hcp-4 |
| Gene |
UniProtKB-ID:
CENPC_HUMAN
UniprotKB:
Q03188
UniParc:
UPI00003507BC,
UPI00004135A3
EMBL:
CH471057,
AF151723,
BC030695,
BC041117,
M95724,
AC104806,
AC109356
Ensembl:
ENSG00000145241
KO:
hsa:1060
|
| Nucleutide sequences |
EMBL-CDS:
AAH30695.1,
EAX05545.1,
AAA51974.1,
AAF73191.1,
AAH41117.1
Ensembl_TRS:
ENST00000273853,
ENST00000506882
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000426078,
ENSP00000273853
RefSeq:
NP_001803.2,
NP_001349410.1,
XP_011529844.1
|
| Others |
UniRef100:
UniRef100_Q03188
UniRef90:
UniRef90_Q03188
UniRef50:
UniRef50_Q03188
UniGene:
Hs.479867
CCDS:
CCDS47063.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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