| Type | Description |
|---|---|
| Definition | extra spindle pole bodies 1, separase |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 12:47:00 | results indicate that cyclin B2/CDK1 is also responsible for separase inhibition via inhibitory phosphorylation to regulate chromosome separation in oocyte meiosis, which may not occur in other cell types. | 31704793 |
| 2019-10-05 10:44:00 | Thus, tethering of separase to DSBs and confined cohesin cleavage promote DSB repair in G2 cells. Importantly, this conserved interphase function of separase protects mammalian cells from oncogenic transformation. | 30305303 |
| 2016-08-20 10:17:00 | Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway. | 26858254 |
| 2015-01-24 11:44:00 | Separase-overexpressing mammary cells are not only susceptible to chromosomal missegregation-induced aneuploidy but also other genetic instabilities | 24276237 |
| 2012-04-14 10:49:00 | With the continual loss of cohesins from chromosomes that occurs throughout the natural reproductive lifespan, tight regulation of separase in oocytes may be particularly important to maintain cohesion and prevent aneuploidy. | 21865557 |
| Type | IDs |
|---|---|
| Synonymous | AL024103, AU045071, Cerp, ESP1, PRCE, SSE |
| Gene |
UniProtKB-ID:
ESPL1_MOUSE
UniprotKB:
P60330
UniParc:
UPI000021575B
EMBL:
AK129072,
BC145846
Ensembl:
ENSMUSG00000058290
KO:
mmu:105988
|
| Nucleutide sequences |
EMBL-CDS:
AAI45847.1,
BAC97882.1
Ensembl_TRS:
ENSMUST00000064924,
ENSMUST00000229050
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000155304,
ENSMUSP00000064465
RefSeq:
XP_036014955.1,
NP_001343241.1,
NP_001014976.1,
XP_006520322.1,
XP_036014956.1,
XP_006520321.1
|
| Others |
UniRef100:
UniRef100_P60330
UniRef90:
UniRef90_P60330
UniRef50:
UniRef50_P60330
UniGene:
Mm.288324
CCDS:
CCDS27878.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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