| Type | Description |
|---|---|
| Definition | endoplasmic reticulum to nucleus signaling 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-29 11:59:00 | A positive feedback bistable ERN2-XBP1S pathway regulates MUC5B-dominated mucus obstruction in idiopathic pulmonary fibrosis (IPF), providing an unfolded protein response-dependent mechanism linking the MUC5B promoter rs35705950 polymorphism with IPF pathogenesis. | 30973754 |
| 2020-02-08 10:52:00 | IRE1beta acts as a dominant-negative suppressor of IRE1alpha and affect how barrier epithelial cells manage the response to stress at the host-environment interface. | 31985747 |
| 2017-10-14 10:59:00 | ER stress-regulated IRE1 dependent decay is involved in regulation of hepatic diseases. (review) | 27774654 |
| 2013-06-15 11:00:00 | The luminal event mediated by IRE1beta involves direct interaction with unfolded proteins rather than association/dissociation with BiP. | 23236464 |
| 2011-03-19 10:53:00 | Data show that IRE1beta represses translation on the ER membrane but not in the cytosol, and that this selective repression depends on the RNase activity of IRE1beta. | 21146530 |
| Type | IDs |
|---|---|
| Synonymous | IRE1-BETA, IRE1b, IRE2p, hIRE2p |
| Gene |
UniProtKB-ID:
ERN2_HUMAN,
A5YM46_HUMAN,
E7ETG2_HUMAN,
A5YM65_HUMAN
UniprotKB:
Q76MJ5,
A5YM46,
E7ETG2,
A5YM65
UniParc:
UPI000004A5C0,
UPI00015657CA,
UPI0001AE6828,
UPI0001565781
EMBL:
EF560720,
KC877598,
EF560739,
AB047079,
AC008870,
AK131280,
KC877599,
AC012317
Ensembl:
ENSG00000134398
KO:
hsa:10595
|
| Nucleutide sequences |
EMBL-CDS:
BAD18455.1,
BAB21297.1,
ABQ59030.1,
ABQ59049.1
Ensembl_TRS:
ENST00000256797,
ENST00000457008
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000256797,
ENSP00000413812
RefSeq:
XP_011544014.1,
XP_011544010.1,
XP_011544015.1,
NP_001295149.2,
NP_150296.4,
XP_011544011.1,
XP_011544013.1
|
| Others |
UniRef100:
UniRef100_E7ETG2,
UniRef100_Q76MJ5,
UniRef100_A5YM65,
UniRef100_A5YM46
UniRef90:
UniRef90_Q76MJ5
UniRef50:
UniRef50_Q76MJ5
UniGene:
Hs.592041
CCDS:
CCDS32407.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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