| Type | Description |
|---|---|
| Definition | secretagogin, EF-hand calcium binding protein |
| Date | Results | Publications |
|---|---|---|
| 2020-03-14 11:33:00 | In this study, the authors report the identification of an ultrarare missense variant (NM_006998.3:c.230G > A;p.Arg77His) in the SCGN gene causing Mendelian early-onset ulcerative colitis. | 31663849 |
| 2018-09-15 11:33:00 | the overexpression of SCGN in SW480 human colorectal cancer cells promoted cell apoptosis and inhibited cell migration and invasion. | 29499408 |
| 2018-09-01 10:54:00 | Glucose-dependent de-SUMOylation of tomosyn1 at K298 releases syntaxin1A and controls the amplification of exocytosis in concert with a recently-identified tomosyn1-interacting partner; the Ca(2+)-binding protein secretagogin, which dissociates from tomosyn1 in response to Ca(2+)-raising stimuli and is required for insulin granule trafficking and exocytosis downstream of Ca(2+) influx. | 28325894 |
| 2018-08-04 10:06:00 | secretagogin is a potential biomarker, reflecting stress and islet cell dysfunction in T2D patients | 29702679 |
| 2018-04-14 10:25:00 | Secretagogin-dependent MMP2 release from neurons regulates neuroblast migration. | 28223495 |
| Type | IDs |
|---|---|
| Synonymous | CALBL, DJ501N12.8, SECRET, SEGN, setagin |
| Gene |
UniProtKB-ID:
SEGN_HUMAN
UniprotKB:
O76038
UniParc:
UPI000013580E
EMBL:
AK289477,
BC000336,
CH471087,
AL512384,
Y16752,
BC003036,
AL022170
Ensembl:
ENSG00000079689
KO:
hsa:10590
|
| Nucleutide sequences |
EMBL-CDS:
AAH00336.1,
BAF82166.1,
AAH03036.1,
CAA76365.1,
EAW55487.1
Ensembl_TRS:
ENST00000377961
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000367197
RefSeq:
NP_008929.2,
XP_016865670.1
|
| Others |
UniRef100:
UniRef100_O76038
UniRef90:
UniRef90_O76038
UniRef50:
UniRef50_O76038
UniGene:
Hs.116428
CCDS:
CCDS4561.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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