| Type | Description |
|---|---|
| Definition | ADP ribosylation factor guanine nucleotide exchange factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:12:00 | BIG1 controls macrophage pro-inflammatory responses through ARF3-mediated PI(4,5)P2 synthesis. | 32415087 |
| 2020-06-06 12:28:00 | BIG1 and BIG2 knockdown significantly decreased the levels of VEGF mRNA and protein in glioblastoma U251 cells and HUVECs. Furthermore, depletion of BIG1 and BIG2 inhibited HUVEC angiogenesis by diminishing cell migration. | 31199673 |
| 2017-11-26 00:37:00 | The findings provide structural insight into how Arf1 GEFs, and hence active Arf1, achieve their correct subcellular distribution. | 27373159 |
| 2017-04-08 10:17:00 | The data demonstrate a novel and unexpected function of BIG1 that regulates TNFR1 signaling by targeting TRAF2. | 27834853 |
| 2016-12-24 11:13:00 | Both phospholipase D activity and vesicular trafficking were required for effects of BIG1 and BIG2 on beta-catenin activation. Levels of beta-catenin S675 and beta-catenin association with BIG1, and BIG2 were also diminished after BIG1/BIG2 depletion. | 27162341 |
| Type | IDs |
|---|---|
| Synonymous | ARFGEP1, BIG1, P200 |
| Gene |
UniProtKB-ID:
BIG1_HUMAN,
A0A024R7X0_HUMAN
UniprotKB:
Q9Y6D6,
A0A024R7X0
UniParc:
UPI000013D275
EMBL:
AF111162,
CH471068,
AL117446,
AF084520,
AK001788
Ensembl:
ENSG00000066777
KO:
hsa:10565
|
| Nucleutide sequences |
EMBL-CDS:
CAB55931.1,
AAD38427.1,
AAD43651.1,
BAA91912.1,
EAW86935.1,
EAW86936.1
Gene_ORFName:
hCG_27804
Ensembl_TRS:
ENST00000262215
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000262215
RefSeq:
XP_005251193.1,
NP_006412.2,
XP_005251191.1,
XP_005251192.1
|
| Others |
UniRef100:
UniRef100_Q9Y6D6
UniRef90:
UniRef90_Q9Y6D6
UniRef50:
UniRef50_Q9Y6D6
UniGene:
Hs.656902
CCDS:
CCDS6199.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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