| Type | Description |
|---|---|
| Definition | ADP ribosylation factor guanine nucleotide exchange factor 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 12:28:00 | BIG1 and BIG2 knockdown significantly decreased the levels of VEGF mRNA and protein in glioblastoma U251 cells and HUVECs. Furthermore, depletion of BIG1 and BIG2 inhibited HUVEC angiogenesis by diminishing cell migration. | 31199673 |
| 2016-12-24 11:13:00 | Both phospholipase D activity and vesicular trafficking were required for effects of BIG1 and BIG2 on beta-catenin activation. Levels of beta-catenin S675 and beta-catenin association with BIG1, and BIG2 were also diminished after BIG1/BIG2 depletion. | 27162341 |
| 2014-09-20 11:52:00 | Description of a novel ARFGEF2 mutation in five related patients presenting with West syndrome, microcephaly, periventricular heterotopia and thin corpus callosum. | 23812912 |
| 2014-07-05 11:15:00 | The clinical phenotype associated with mutations in ARFGEF2 is relatively homogeneous in the families report. | 23755938 |
| 2013-11-30 11:02:00 | Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex. | 23918382 |
| Type | IDs |
|---|---|
| Synonymous | BIG2, PVNH2, dJ1164I10.1 |
| Gene |
UniProtKB-ID:
BIG2_HUMAN,
Q59FR3_HUMAN,
Q86TH5_HUMAN
UniprotKB:
Q9Y6D5,
Q59FR3,
Q86TH5
UniParc:
UPI000018CE90,
UPI00004F6CA9,
UPI000013D378
EMBL:
AL049537,
AB209397,
AF084521,
AL121903,
BC050449
Ensembl:
ENSG00000124198
KO:
hsa:10564
|
| Nucleutide sequences |
EMBL-CDS:
AAD38428.1,
BAD92634.1,
AAH50449.1
Ensembl_TRS:
ENST00000371917
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360985
RefSeq:
XP_005260309.1,
NP_006411.2
|
| Others |
UniRef100:
UniRef100_Q9Y6D5,
UniRef100_Q86TH5
UniRef90:
UniRef90_Q9Y6D5,
UniRef90_Q86TH5
UniRef50:
UniRef50_Q9Y6D5,
UniRef50_A0A226MMW9
UniGene:
Hs.62578
CCDS:
CCDS13411.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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