| Type | Description |
|---|---|
| Definition | 1-acylglycerol-3-phosphate O-acyltransferase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:52:00 | Congenital Generalized Lipoatrophy (Berardinelli-Seip Syndrome) Type 1: Description of Novel AGPAT2 Homozygous Variants Showing the Highly Heterogeneous Presentation of the Disease. | 32117065 |
| 2020-12-05 12:57:00 | Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation. | 32094408 |
| 2018-12-01 12:16:00 | The findings demonstrate that AGPAT2, which is mutated in patients with congenital generalized lipodystrophy and over-expressed in different types of cancer, is a direct transcriptional target of HIF-1, suggesting that upregulation of lipid storage by HIF-1 plays an important role in adaptation and survival of cancer cells under low oxygen conditions. | 29908837 |
| 2017-05-06 11:24:00 | Results show that LPAATbeta had high expression in osteosarcoma patients who received cisplatin treatment and cisplatin-resistant cancer cell lines. In vitro and in vivo studies provide evidence that LPAATB plays an important role in osteosarcoma. | 28035350 |
| 2014-11-08 12:09:00 | Data show that missense mutation c.299G>A changes serine in the acyltransferase NHX4D motif of AGPAT2, and intronic c.493-1G>C mutation destroy a splicing site that leads to exon 4 skipping and deletion of whole AGPAT2 substrate binding domain. | 24498038 |
| Type | IDs |
|---|---|
| Synonymous | 1-AGPAT2, BSCL, BSCL1, LPAAB, LPAAT-beta |
| Gene |
UniProtKB-ID:
PLCB_HUMAN,
A0A024R8I7_HUMAN,
A0A024R8F9_HUMAN
UniprotKB:
O15120,
A0A024R8I7,
A0A024R8F9
UniParc:
UPI000002B133,
UPI0000131BD3
EMBL:
HM005456,
AF011374,
U56418,
AL590226,
CH471090,
BC000026,
BC004529,
AF000237
Ensembl:
ENSG00000169692
KO:
hsa:10555
|
| Nucleutide sequences |
EMBL-CDS:
AAH04529.1,
AAB64299.1,
EAW88251.1,
EAW88249.1,
AAH00026.1,
AAB58776.2,
AAC51649.1,
EAW88250.1,
EAW88252.1,
AEE61054.1
Gene_ORFName:
hCG_27224,
hCG_27224
Ensembl_TRS:
ENST00000371694,
ENST00000371696,
ENST00000538402
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360759,
ENSP00000438919,
ENSP00000360761
RefSeq:
NP_006403.2,
NP_001012745.1
|
| Others |
UniRef100:
UniRef100_O15120,
UniRef100_A0A024R8F9
UniRef90:
UniRef90_O15120
UniRef50:
UniRef50_O15120
UniGene:
Hs.320151
CCDS:
CCDS35181.1,
CCDS7003.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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